Anti-GHRHR antibody (ab28692)
Key features and details
- Rabbit polyclonal to GHRHR
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-GHRHR antibody
See all GHRHR primary antibodies -
Description
Rabbit polyclonal to GHRHR -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide:
RTRAKWTTPSRSAAKVLTSM
conjugated to KLH, corresponding to amino acids 403-422 of Human GHRHR -
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
Preservative: 0.05% Sodium azide
Constituent: Whole serum -
Concentration information loading...
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Purity
Whole antiserum -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab28692 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
1/1000. Perform heat mediated antigen retrieval via the microwave method before commencing with IHC staining protocol.
Perform heat mediated antigen retrieval via the microwave method for 20 minutes in citric acid at pH 6.0. |
Notes |
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IHC-P
1/1000. Perform heat mediated antigen retrieval via the microwave method before commencing with IHC staining protocol. Perform heat mediated antigen retrieval via the microwave method for 20 minutes in citric acid at pH 6.0. |
Target
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Function
Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion. -
Tissue specificity
Pituitary gland. -
Involvement in disease
Defects in GHRHR are a cause of growth hormone deficiency isolated type 1B (IGHD1B) [MIM:612781]; also known as dwarfism of Sindh. IGHD1B is an autosomal recessive deficiency of GH which causes short stature. IGHD1B patients have low but detectable levels of GH. -
Sequence similarities
Belongs to the G-protein coupled receptor 2 family. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 2692 Human
- Omim: 139191 Human
- SwissProt: Q02643 Human
- Unigene: 767 Human
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Alternative names
- GHRFR antibody
- GHRH R antibody
- GHRH receptor antibody
see all
Images
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (26)
ab28692 has been referenced in 26 publications.
- Kubra KT et al. Growth Hormone-Releasing Hormone Antagonist JV-1-36 Suppresses Reactive Oxygen Species Generation in A549 Lung Cancer Cells. Endocrines 3:813-820 (2022). PubMed: 36540765
- Akhter MS & Barabutis N Suppression of reactive oxygen species in endothelial cells by an antagonist of growth hormone-releasing hormone. J Biochem Mol Toxicol 35:e22879 (2021). PubMed: 34369038
- Pech-Pool S et al. Thyrotropin-Releasing Hormone (TRH) and Somatostatin (SST), but not Growth Hormone-Releasing Hormone (GHRH) nor Ghrelin (GHRL), Regulate Expression and Release of Immune Growth Hormone (GH) from Chicken Bursal B-Lymphocyte Cultures. Int J Mol Sci 21:N/A (2020). PubMed: 32093298
- Barabutis N et al. GHRH Antagonists Protect Against Hydrogen Peroxide-Induced Breakdown of Brain Microvascular Endothelium Integrity. Horm Metab Res 52:336-339 (2020). PubMed: 32403147
- Uddin MA et al. GHRH antagonists support lung endothelial barrier function. Tissue Barriers 7:1669989 (2019). PubMed: 31578921