Overview

  • Product name

    Ginkgolic acid, Naturally occurring compound
  • Description

    Naturally occurring compound. Various pharmacological effects.
  • Biological description

    Naturally occurring compound. Various pharmacological effects. Potent, cell-permeable protease and SUMO inhibitor (IC60 = 90 nM, HIV-1 protease). Inhibits HIV-infection unlike related ginkgolides A (ab142602) and B (ab142603). Shows antiproliferative and apoptotic effects. Shows anxiolytic effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    22910-60-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-Hydroxy-6-(8Z)-8-pentadecenylbenzoic acid
  • Molecular weight

    346.51
  • Molecular formula

    C22H34O3
  • PubChem identifier

    5281858
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 25 mM and in DMSO to 25mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCCCCCC=CCCCCCCCC1=C(C(=CC=C1)O)C(=O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Xia H  et al. Identification of ginkgolic acid (15:1) metabolites in rats following oral administration by high-performance liquid chromatography coupled to tandem mass spectrometry. Xenobiotica 43:454-60 (2013). Read more (PubMed: 23205533) »
  • Lü JM  et al. Ginkgolic acid inhibits HIV protease activity and HIV infection in vitro. Med Sci Monit 18:BR293-298 (2012). Read more (PubMed: 22847190) »
  • Zhou C  et al. Antitumor effects of ginkgolic acid in human cancer cell occur via cell cycle arrest and decrease the Bcl-2/Bax ratio to induce apoptosis. Chemotherapy 56:393-402 (2010). Read more (PubMed: 20948210) »
  • Fukuda I  et al. Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate. Chem Biol 16:133-40 (2009). Read more (PubMed: 19246003) »
  • Satyan KS  et al. Anxiolytic activity of ginkgolic acid conjugates from Indian Ginkgo biloba. Psychopharmacology (Berl) 136:148-52 (1998). Read more (PubMed: 9551771) »
See 1 Publication for this product

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