Overview

  • Product name
    Ginkgolide B
  • Description
    Platelet -activating factor (PAF) antagonist
  • Biological description
    Platelet -activating factor (PAF) antagonist (Ki = 1.3 μM). A biologically active terpenic lactone. Anti-inflammatory and neuroprotective effects in vivo. Inhibits atherosclerosis in vivo.
  • Purity
    > 95%

Properties

  • Molecular weight
    424.40
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C20H24O10
  • CAS Number
    15291-77-7
  • PubChem identifier
    17751009
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO to 100 mM and in ethanol to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CC1C(=O)OC2C1(C34C(=O)OC5C3(C2O)C6(C(C5)C(C)(C)C)C(C(=O)OC6O4)O)O
  • Source

    Gingo biloba.

  • Research areas

References

This product has been referenced in:
  • Singh P  et al. Platelet-activating factor (PAF)-antagonists of natural origin. Fitoterapia 84:180-201 (2013). Read more (PubMed: 23160091) »
  • Liu X  et al. Ginkgolide B reduces atherogenesis and vascular inflammation in ApoE(-/-) mice. PLoS One 7:e36237 (2012). Read more (PubMed: 22662117) »
  • Xie J  et al. Simultaneous determination of ginkgolides A, B, C and bilobalide in plasma by LC-MS/MS and its application to the pharmacokinetic study of Ginkgo biloba extract in rats. J Chromatogr B Analyt Technol Biomed Life Sci 864:87-94 (2008). Read more (PubMed: 18295555) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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