Anti-GIP antibody [04] (ab30679)
Key features and details
- Mouse monoclonal [04] to GIP
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG1
Overview
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Product name
Anti-GIP antibody [04]
See all GIP primary antibodies -
Description
Mouse monoclonal [04] to GIP -
Host species
Mouse -
Specificity
Ab30679 recognises GIP. It cross reacts up to 10% with PACAP and GLP2 but <0.1% with glucagon, GLP1 or VIP. -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic human GIP coupled to carrier. The immunogen was adsorbed onto Al(OH)3 and emulsified in Freund's incomplete adjuvant.
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General notes
Fusion partner: SP2/mIL6.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.40
Preservative: 0.097% Sodium azide
Constituents: 0.0268% PBS, 0.87% Sodium chloride -
Concentration information loading...
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Purity
Protein A purified -
Primary antibody notes
Fusion partner: SP2/mIL6. -
Clonality
Monoclonal -
Clone number
04 -
Isotype
IgG1 -
Light chain type
kappa -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab30679 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P | (1) |
1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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Notes |
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IHC-P
1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Target
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Function
Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion. -
Sequence similarities
Belongs to the glucagon family. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 2695 Human
- Omim: 137240 Human
- SwissProt: P09681 Human
- Unigene: 1454 Human
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Alternative names
- Gastric Inhibitory Peptide antibody
- Gastric inhibitory polypeptide antibody
- Gastric inhibitory polypeptide precursor antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (8)
ab30679 has been referenced in 8 publications.
- Yan S et al. Intestinal Gpr17 deficiency improves glucose metabolism by promoting GLP-1 secretion. Cell Rep 38:110179 (2022). PubMed: 34986353
- Chu L et al. In vivo drug discovery for increasing incretin-expressing cells identifies DYRK inhibitors that reinforce the enteroendocrine system. Cell Chem Biol 29:1368-1380.e5 (2022). PubMed: 35998625
- McKimpson WM et al. FOXO1 Is Present in Stomach Epithelium and Determines Gastric Cell Distribution. Gastro Hep Adv 1:733-745 (2022). PubMed: 36117550
- Vazquez SE et al. Identification of novel, clinically correlated autoantigens in the monogenic autoimmune syndrome APS1 by proteome-wide PhIP-Seq. Elife 9:N/A (2020). PubMed: 32410729
- Palha AM et al. Differential GIP/GLP-1 intestinal cell distribution in diabetics' yields distinctive rearrangements depending on Roux-en-Y biliopancreatic limb length. J Cell Biochem 119:7506-7514 (2018). PubMed: 29761876
- Lim DM et al. Difference in protective effects of GIP and GLP-1 on endothelial cells according to cyclic adenosine monophosphate response. Exp Ther Med 13:2558-2564 (2017). PubMed: 28565879
- Deane AM et al. The effects of critical illness on intestinal glucose sensing, transporters, and absorption. Crit Care Med 42:57-65 (2014). PubMed: 23963126
- Young RL et al. Disordered control of intestinal sweet taste receptor expression and glucose absorption in type 2 diabetes. Diabetes 62:3532-41 (2013). Human . PubMed: 23761104