Overview

  • Product name

    Anti-GJA3/Cx46 antibody [11H16L33]
    See all GJA3/Cx46 primary antibodies
  • Description

    Rabbit monoclonal [11H16L33] to GJA3/Cx46
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse
    Predicted to work with: Rat
  • Immunogen

    Synthetic peptide corresponding to Mouse GJA3/Cx46 aa 131-144.
    Sequence:

    GSPRDPPLRDDRGK


    Database link: Q64448

  • Positive control

    • Mouse lens lysate; Mouse lens tissue.
  • General notes

    Previously labelled as GJA3. 

Properties

Applications

Our Abpromise guarantee covers the use of ab203564 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml.
IHC-P Use a concentration of 0.5 - 2 µg/ml.

Target

  • Function

    One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
  • Involvement in disease

    Defects in GJA3 are the cause of cataract zonular pulverulent cataract type 3 (CZP3) [MIM:601885]. A form of zonular cataract. Zonular or lamellar cataracts are opacities, broad or narrow, usually consisting of powdery white dots affecting only certain layers or zones between the cortex and nucleus of an otherwise clear lens. The opacity may be so dense as to render the entire central region of the lens completely opaque, or so translucent that vision is hardly if at all impeded. Zonular cataracts generally do not involve the embryonic nucleus, though sometimes they involve the fetal nucleus. Usually sharply separated from a clear cortex outside them, they may have projections from their outer edges known as riders or spokes.
  • Sequence similarities

    Belongs to the connexin family. Alpha-type (group II) subfamily.
  • Cellular localization

    Cell membrane. Cell junction > gap junction.
  • Information by UniProt
  • Database links

  • Alternative names

    • CAE3 antibody
    • Connexin 46 antibody
    • Connexin-46 antibody
    • Connexin46 antibody
    • Cx46 antibody
    • CXA3_HUMAN antibody
    • CZP3 antibody
    • Gap junction alpha 3 protein antibody
    • Gap junction alpha-3 protein antibody
    • Gap junction protein, alpha 3, 46kD (connexin 46) antibody
    • Gap junction protein, alpha 3, 46kDa (connexin 46) antibody
    • Gap junction protein, alpha 3, 46kDa antibody
    • Gja3 antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded mouse lens tissue labeling GJA3/Cx46 with ab203564 at 1 µg/mL.

  • Anti-GJA3/Cx46 antibody [11H16L33] (ab203564) at 2 µg/ml + mouse lens lysate

References

ab203564 has not yet been referenced specifically in any publications.

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