Anti-GlcAT-I antibody - Conformation-Specific (ab170795)

Overview

  • Product name
    Anti-GlcAT-I antibody - Conformation-Specific
  • Description
    Rabbit polyclonal to GlcAT-I - Conformation-Specific
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human GlcAT-I aa 300-329 (C terminal) conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
    Database link: O94766

  • Positive control
    • CEM cell line lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab170795 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 37 kDa.

Target

  • Function
    Glycosaminoglycans biosynthesis. Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate. Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4-Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans. Can also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins. Shows strict specificity for Gal-beta-1,3-Gal-beta-1,4-Xyl, exhibiting negligible incorporation into other galactoside substrates including Galbeta1-3Gal beta1-O-benzyl, Galbeta1-4GlcNAc and Galbeta1-4Glc.
  • Tissue specificity
    Ubiquitous (but weakly expressed in all tissues examined).
  • Pathway
    Protein modification; protein glycosylation.
  • Involvement in disease
    Defects in B3GAT3 are the cause of multiple joint dislocations short stature craniofacial dysmorphism and congenital heart defects (JDSSDHD) [MIM:245600]. An autosomal recessive disease characterized by dysmorphic facies, bilateral dislocations of the elbows, hips, and knees, clubfeet, and short stature, as well as cardiovascular defects.
  • Sequence similarities
    Belongs to the glycosyltransferase 43 family.
  • Post-translational
    modifications
    N-glycosylated.
  • Cellular localization
    Golgi apparatus membrane. Golgi apparatus > cis-Golgi network.
  • Information by UniProt
  • Database links
  • Alternative names
    • 3-Gal-R glucuronyltransferase antibody
    • 3-glucuronyltransferase 3 antibody
    • B3GA3_HUMAN antibody
    • B3GAT3 antibody
    • Beta 1,3 glucuronyltransferase 3 (glucuronosyltransferase I) antibody
    • Beta 1,3 glucuronyltransferase 3 antibody
    • Beta-1 antibody
    • EC 2.4.1.135 antibody
    • Galactosylgalactosylxylosylprotein 3 beta glucuronosyltransferase 3 antibody
    • Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 antibody
    • GlcAT-I antibody
    • GLCATI antibody
    • glcUAT I antibody
    • GlcUAT-I antibody
    • GlcUATI antibody
    • Glucuronosyltransferase I antibody
    • Sqv 8 like protein antibody
    • UDP GlcUA:Gal beta 1,3 Gal R glucuronyltransferase antibody
    • UDP GlcUA:Gal beta 1,3 GalR glucuronyltransferase antibody
    • UDP-GlcUA:Gal beta-1 antibody
    see all

Images

  • Anti-GlcAT-I antibody - Conformation-Specific (ab170795) at 1/100 dilution + CEM cell line lysates at 35 µg

    Predicted band size: 37 kDa

References

ab170795 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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