Overview

  • Product name

    Gliclazide, SUR-1 channel blocker
  • Description

    Selective SUR-1 channel blocker
  • Biological description

    Selective sulfonylurea-1 (SUR-1) channel blocker (IC50 values are 0.2 and 20 μM for SUR-1 and SUR-2A respectively). Stimulates insulin secretion by blocking ATP-sensitive K+ channels. Shows hypglycemic effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    21187-98-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-(3,3a,4,5,6,6a-Hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(4-methylphenyl)sulfonylurea
  • Molecular weight

    323.41
  • Molecular formula

    C15H21N3O3S
  • PubChem identifier

    3475
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=CC=C(C=C1)S(=O)(=O)NC(=O)NN2CC3CCCC3C2
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Jarrard RE  et al. Potentiation of sulfonylurea action by an EPAC-selective cAMP analog in INS-1 cells: comparison of tolbutamide and gliclazide and a potential role for EPAC activation of a 2-APB-sensitive Ca2+ influx. Mol Pharmacol 83:191-205 (2013). Read more (PubMed: 23071106) »
  • Sun WP  et al. [The effects of insulin and gliclazide therapy on endoplasmic reticulum stress and insulin sensitivity in liver of type 2 diabetic rats]. Zhonghua Nei Ke Za Zhi 51:638-41 (2012). Read more (PubMed: 23158865) »
  • Lawrence CL  et al. Gliclazide produces high-affinity block of KATP channels in mouse isolated pancreatic beta cells but not rat heart or arterial smooth muscle cells. Diabetologia 44:1019-25 (2001). Read more (PubMed: 11484080) »

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