Overview

  • Product name

    Glimepiride, cardiac KATP channel blocker
  • Description

    Potent cardiac KATP channel blocker
  • Biological description

    Potent cardiac Kir6 (KATP) channel blocker (IC50 = 6.8 nM). Antidiabetic agent. Orally active and active in vivo.
  • Purity

    > 98%
  • CAS Number

    93479-97-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-Ethyl-3-methyl-N-[2-[4-[(4-methylcyclohexyl)carbamoylsulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide
  • Molecular weight

    490.62
  • Molecular formula

    C24H34N4O5S
  • PubChem identifier

    3476
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCC1=C(CN(C1=O)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCC(CC3)C)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Veeresham C  et al. Effect of piperine on the pharmacokinetics and pharmacodynamics of glimepiride in normal and streptozotocin-induced diabetic rats. Nat Prod Commun 7:1283-6 (2012). Read more (PubMed: 23156991) »
  • Mwafy SN & Yassin MM Antidiabetic activity evaluation of glimepiride and Nerium oleander extract on insulin, glucose levels and some liver enzymes activities in experimental diabetic rat model. Pak J Biol Sci 14:984-90 (2011). Read more (PubMed: 22514888) »
  • Lawrence CL  et al. Effect of metabolic inhibition on glimepiride block of native and cloned cardiac sarcolemmal K(ATP) channels. Br J Pharmacol 136:746-52 (2002). Read more (PubMed: 12086984) »

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