Key features and details
- Specific NF-κB inhibitor
- CAS Number: 67-99-2
- Purity: > 98%
- Soluble in DMSO and ethanol
- Form / State: Solid
- Source: Synthetic
Product nameGliotoxin, NF-kappaB inhibitor
DescriptionSpecific NF-κB inhibitor
Biological descriptionSpecfic NF-κB inhibitor. Induces apoptosis and suppresses TNF-α gene expression in vitro. Farnesyltransferase and geranylgeranyltransferase I inhibitor (IC50 = 80 and 17 μM respectively). Mycotoxin antibiotic. Immunosuppressive, anti-inflammatory and antitumor agent. Active in vivo and in vitro. Orally active.
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO and ethanol
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Cell Biology
- Proteolysis / Ubiquitin
- Proteasome / Ubiquitin
- Ubiquitin E3 Enzymes
- RING Finger E3 Ligase
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab142437 has been referenced in 3 publications.
- Wu M et al. LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores. Nat Commun 10:273 (2019). PubMed: 30655516
- Zhang C et al. Gliotoxin Induces Cofilin Phosphorylation to Promote Actin Cytoskeleton Dynamics and Internalization of Aspergillus fumigatus Into Type II Human Pneumocyte Cells. Front Microbiol 10:1345 (2019). PubMed: 31275272
- Zhang C et al. Gliotoxin destructs the pulmonary epithelium barrier function by reducing cofilin oligomer formation to promote the dissolution of actin stress fibers. Microb Pathog 123:169-176 (2018). PubMed: 30017941