Overview

  • Product name

    Gliotoxin, NF-kappaB inhibitor
  • Description

    Specific NF-κB inhibitor
  • Biological description

    Specfic NF-κB inhibitor. Induces apoptosis and suppresses TNF-α gene expression in vitro. Farnesyltransferase and geranylgeranyltransferase I inhibitor (IC50 = 80 and 17 μM respectively). Mycotoxin antibiotic. Immunosuppressive, anti-inflammatory and antitumor agent. Active in vivo and in vitro. Orally active.
  • Purity

    > 98%
  • CAS Number

    67-99-2
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Vigushin DM  et al. Gliotoxin is a dual inhibitor of farnesyltransferase and geranylgeranyltransferase I with antitumor activity against breast cancer in vivo. Med Oncol 21:21-30 (2004). Read more (PubMed: 15034210) »
  • Herfarth H  et al. Nuclear factor-kappa B activity and intestinal inflammation in dextran sulphate sodium (DSS)-induced colitis in mice is suppressed by gliotoxin. Clin Exp Immunol 120:59-65 (2000). Read more (PubMed: 10759764) »
  • Fitzpatrick LR  et al. In vitro and in vivo effects of gliotoxin, a fungal metabolite: efficacy against dextran sodium sulfate-induced colitis in rats. Dig Dis Sci 45:2327-36 (2000). Read more (PubMed: 11258552) »
  • Waring P  et al. Apoptosis induced by gliotoxin is preceded by phosphorylation of histone H3 and enhanced sensitivity of chromatin to nuclease digestion. J Biol Chem 272:17929-36 (1997). Read more (PubMed: 9218417) »
See all 2 Publications for this product

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