Overview

  • Product name

    Gliquidone, ATP-dependent Kchannel blocker
  • Description

    Potent ATP-dependent K+ channel blocker
  • Biological description

    Potent ATP-dependent K+ channel blocker (IC50 = 27 nM). Increases voltage-dependent Ca2+ influx. Increases insulin release and shows antidiabetic effects in vivo. Orally active.
  • CAS Number

    33342-05-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-Cyclohexyl-3-[4-[2-(7-methoxy-4,4-dimethyl-1,3-dioxoisoquinolin-2-yl)ethyl]phenyl]sulfonylurea
  • Molecular weight

    527.63
  • Molecular formula

    C27H33N3O6S
  • PubChem identifier

    91610
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1(C=CC(=CC=1)CCN2C(C3C=C(C=CC(C(C2=O)(C)C)=3)OC)=O)S(=O)(=O)NC(=O)NC4CCCCC4
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Ke JT  et al. Gliquidone decreases urinary protein by promoting tubular reabsorption in diabetic Goto-Kakizaki rats. J Endocrinol 220:129-41 (2014). Read more (PubMed: 24254365) »
  • Koyuturk M  et al. Effect of glurenorm on immunohistochemical changes in pancreatic beta cells of rats in experimental diabetes. Indian J Exp Biol 43:268-71 (2005). Read more (PubMed: 15816415) »
  • Yanardag R  et al. Protective effects of glurenorm (gliquidone) treatment on the liver injury of experimental diabetes. Drug Chem Toxicol 28:483-97 (2005). Read more (PubMed: 16298877) »

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