Overview

  • Product name

  • Description

    Rabbit polyclonal to GLIS3
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human GLIS3 aa 130-165 conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Sequence:

    SPRHSSTRSHSARSKKRALSLSPLSDGIGIDFNTII


    Database link: Q8NEA6

  • Positive control

    • Rat and human kidney tissues.

Properties

Applications

Our Abpromise guarantee covers the use of ab203121 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500.

(or 1/50 - 1/200 using a fluorescent secondary antibody).

Target

  • Relevance

    GLIS3 is a member of the GLI similar zinc finger protein family, and encodes a nuclear protein with five C2H2 type zinc finger domains. It functions as both an activator and repressor of transcription, and is specifically involved in the development of pancreatic beta cells, thyroid, eye, liver and kidney. Mutations in this gene have been associated with neonatal diabetes and congenital hypothyroidism (NDH). Alternatively spliced variants that encode different protein isoforms have been described but the full length nature of only two have been determined.
  • Cellular localization

    Nuclear
  • Database links

  • Alternative names

    • FLJ38999 antibody
    • FLJ90578 antibody
    • GLI similar 3 antibody
    • GLI SIMILAR PROTEIN 3 antibody
    • GLIS family zinc finger 3 antibody
    • MGC33662 antibody
    • OK/KNS-cl.4 antibody
    • Zinc finger protein 515 antibody
    • Zinc finger protein GLIS3 antibody
    • ZNF515 antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human kidney tissue labeling GLIS3 with ab203121 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded rat kidney tissue labeling GLIS3 with ab203121 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

References

ab203121 has not yet been referenced specifically in any publications.

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