Overview

  • Product name

    Anti-Glucagon Receptor antibody - N-terminal
    See all Glucagon Receptor primary antibodies
  • Description

    Rabbit polyclonal to Glucagon Receptor - N-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide, corresponding to a region within N terminal amino acids 36-130 of Human Glucagon Receptor

  • Positive control

    • 293T whole cell lysate, H1299 or HeLa cell lysates
      CL1-0 xenograft tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab137649 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/1000. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. Antigen retrieval using heat mediated Tris/EDTA buffer (pH 8.0) is also possible.
WB 1/500 - 1/3000. Predicted molecular weight: 54 kDa.

Target

  • Function

    This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.
  • Sequence similarities

    Belongs to the G-protein coupled receptor 2 family.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Gcgr antibody
    • GGR antibody
    • GL R antibody
    • GL-R antibody
    • GLR antibody
    • GLR_HUMAN antibody
    • Glucagon receptor antibody
    • Glucagon receptor precursor antibody
    • MGC138246 antibody
    see all

Images

  • Anti-Glucagon Receptor antibody - N-terminal (ab137649) at 1/1000 dilution + 293T whole cell lysate at 30 µg

    Predicted band size: 54 kDa



    10% SDS PAGE
  • Immunohistochemical analysis of paraffin embedded CL1-0 xenograft, labelling Glucagon Receptor with ab137649 at 1/100 dilution.

References

This product has been referenced in:

  • Kumar S  et al. Picrorhiza kurroa Enhances ß-Cell Mass Proliferation and Insulin Secretion in Streptozotocin Evoked ß-Cell Damage in Rats. Front Pharmacol 8:537 (2017). IHC . Read more (PubMed: 28878669) »
  • Cegla J  et al. RAMP2 Influences Glucagon Receptor Pharmacology via Trafficking and Signaling. Endocrinology 158:2680-2693 (2017). Read more (PubMed: 28586439) »
See all 3 Publications for this product

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