Glucaric acid calcium salt (Calcium saccharate), beta-glucuronidase inhibitor (ab143496)

Overview

  • Product name

    Glucaric acid calcium salt (Calcium saccharate), beta-glucuronidase inhibitor
  • Description

    Potent β-glucuronidase inhibitor
  • Biological description

    Potent β-glucuronidase inhibitor. Stimulates differentiation and suppresses proliferation. Shows chemopreventive and antitumor effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    5793-89-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Calcium (2S,3S,4S,5R)-2,3,4,5-tetrahydroxyhexanedioate tetrahydrate
  • Molecular weight

    320.30
  • Molecular formula

    C6H16CaO12
  • PubChem identifier

    11954337
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 10 mM (with heating)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C(C(C(C(=O)[O-])O)O)(C(C(=O)[O-])O)O.O.O.O.O.[Ca+2]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Singh J & Gupta KP Calcium glucarate prevents tumor formation in mouse skin. Biomed Environ Sci 16:9-16 (2003). Read more (PubMed: 12747003) »
  • Walaszek Z  et al. Metabolism, uptake, and excretion of a D-glucaric acid salt and its potential use in cancer prevention. Cancer Detect Prev 21:178-90 (1997). Read more (PubMed: 9101079) »
  • Webb TE  et al. Pharmacokinetics relevant to the anti-carcinogenic and anti-tumor activities of glucarate and the synergistic combination of glucarate:retinoid in the rat. Biochem Pharmacol 47:1655-60 (1994). Read more (PubMed: 8185680) »

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