• Nature
  • Amino Acid Sequence
    • Sequence
      A 22 amino acid (amino acids 346 - 367) synthetic peptide whose sequence is from the amino terminus of the human glucocorticoid receptor (GR). The sequence of this peptide is (amino to carboxy terminus): DQKPIFNVIPPIPVGSENWNR - C (The C-terminal cysteine has been added to facilitate conjugation and is not a part of the native human GR sequence)
    • Amino acids
      346 to 366

Associated products


Our Abpromise guarantee covers the use of ab5019 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications


  • Form
  • Additional notes

    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and the human GR, catalog ab3578. Using a solution with equal weights per unit volume of peptide and corresponding antibody will yield a solution with a large molar excess of peptide that is able to competitively bind the antibody.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • GCCR
    • GCR
    • GCRST
    • glucocorticoid nuclear receptor variant 1
    • Glucocorticoid receptor
    • GR
    • GRL
    • Grl1
    • nr3c1
    • Nuclear receptor subfamily 3 group C member 1
    • nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
    see all
  • Function
    Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation.
  • Tissue specificity
    Widely expressed. In the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart.
  • Involvement in disease
    Defects in NR3C1 are a cause of glucocorticoid resistance (GCRES) [MIM:138040]; also known as cortisol resistance. It is a hypertensive, hyperandrogenic disorder characterized by increased serum cortisol concentrations. Inheritance is autosomal dominant.
  • Sequence similarities
    Belongs to the nuclear hormone receptor family. NR3 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • Domain
    Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • Post-translational
    Increased proteasome-mediated degradation in response to glucocorticoids.
    Phosphorylated in the absence of hormone; becomes hyperphosphorylated in the presence of glucocorticoid. The Ser-203-phosphorylated form is mainly cytoplasmic, and the Ser-211-phosphorylated form is nuclear. Transcriptional activity correlates with the amount of phosphorylation at Ser-211.
    Sumoylated; this reduces transcription transactivation.
    Ubiquitinated; restricts glucocorticoid-mediated transcriptional signaling.
  • Cellular localization
    Cytoplasm. Nucleus. Cytoplasmic in the absence of ligand, nuclear after ligand-binding and Nucleus. Localized largely in the nucleus.
  • Information by UniProt


This product has been referenced in:
  • Dayger CA  et al. Physiological correlates of reproductive decisions: Relationships among body condition, reproductive status, and the hypothalamus-pituitary-adrenal axis in a reptile. Horm Behav 100:1-11 (2018). WB . Read more (PubMed: 29452075) »
See 1 Publication for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab5019.
Please use the links above to contact us or submit feedback about this product.


Sign up