Description

Associated products

Specifications

Our Abpromise guarantee covers the use of ab202335 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-Glucose Transporter GLUT1 antibody [EPR3915] (ab115730)

  • Form

    Liquid
  • Additional notes

    This is the blocking peptide for ab115730

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C.

General Info

  • Alternative names

    • Choreoathetosis/spasticity episodic (paroxysmal choreoathetosis/spasticity)
    • CSE
    • DYT17
    • DYT18
    • DYT9
    • EIG12
    • erythrocyte/brain
    • Erythrocyte/hepatoma glucose transporter
    • facilitated glucose transporter member 1
    • Glucose transporter 1
    • Glucose transporter type 1
    • Glucose transporter type 1, erythrocyte/brain
    • GLUT
    • GLUT-1
    • GLUT1
    • GLUT1DS
    • GLUTB
    • GT1
    • GTG1
    • Gtg3
    • GTR1_HUMAN
    • HepG2 glucose transporter
    • HTLVR
    • Human T cell leukemia virus (I and II) receptor
    • MGC141895
    • MGC141896
    • PED
    • RATGTG1
    • Receptor for HTLV 1 and HTLV 2
    • SLC2A1
    • Solute carrier family 2
    • Solute carrier family 2 (facilitated glucose transporter), member 1
    • Solute carrier family 2, facilitated glucose transporter member 1
    see all
  • Function

    Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses.
  • Tissue specificity

    Expressed at variable levels in many human tissues.
  • Involvement in disease

    Defects in SLC2A1 are the cause of glucose transporter type 1 deficiency syndrome (GLUT1DS) [MIM:606777]; also known as blood-brain barrier glucose transport defect. This disease causes a defect in glucose transport across the blood-brain barrier. It is characterized by infantile seizures, delayed development, and acquired microcephaly.
    Defects in SLC2A1 are the cause of dystonia type 18 (DYT18) [MIM:612126]. DYT18 is an exercise-induced paroxysmal dystonia/dyskinesia. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. DYT18 is characterized by attacks of involuntary movements triggered by certain stimuli such as sudden movement or prolonged exercise. In some patients involuntary exertion-induced dystonic, choreoathetotic, and ballistic movements may be associated with macrocytic hemolytic anemia.
  • Sequence similarities

    Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
  • Post-translational
    modifications

    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization

    Cell membrane. Melanosome. Localizes primarily at the cell surface (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • Information by UniProt

References

ab202335 has not yet been referenced specifically in any publications.

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