Overview

  • Product name

  • Description

    Rabbit polyclonal to GluK1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: ICC/IF, WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human GluK1 (internal sequence).
    (Peptide available as ab115358)

  • Positive control

    • rat brain tissue lysate, human brain tissue
  • General notes

     This product was previously labelled as GRIK1

     

Properties

Applications

Our Abpromise guarantee covers the use of ab67317 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 104 kDa (predicted molecular weight: 104 kDa).
IHC-P Use at an assay dependent concentration.

Target

  • Function

    Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.
  • Tissue specificity

    Most abundant in the cerebellum and the suprachiasmatic nuclei (SCN) of the hypothalamus.
  • Sequence similarities

    Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK1 subfamily.
  • Cellular localization

    Cell membrane. Cell junction > synapse > postsynaptic cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • EAA3 antibody
    • EEA3 antibody
    • Excitatory amino acid receptor 3 antibody
    • GLR5 antibody
    • GluR-5 antibody
    • GluR5 antibody
    • GluR6 antibody
    • GluR7 antibody
    • Glutamate receptor 5 antibody
    • Glutamate receptor antibody
    • Glutamate receptor ionotropic kainate 1 antibody
    • GRIK1 antibody
    • GRIK1_HUMAN antibody
    • Human glutamate receptor GLUR5 antibody
    • ionotropic kainate 1 antibody
    • OTTHUMP00000096569 antibody
    see all

Images

  •  ab67317 at 2.5 μg/ml staining of GluK1 in human brain tissue using IHC-P

  • Lane 1 : Anti-GluK1 antibody (ab67317) at 0.5 µg/ml
    Lane 2 : Anti-GluK1 antibody (ab67317) at 1 µg/ml

    All lanes : rat brain tissue lysate

    Lysates/proteins at 15 µg per lane.

    Predicted band size: 104 kDa
    Observed band size: 104 kDa
    Additional bands at: 85 kDa. We are unsure as to the identity of these extra bands.

  • Immunofluorescence of GluK1 in Human Brain cells using ab67317 at 20 ug/ml.

References

ab67317 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab67317.
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