Overview

  • Product name

    Anti-GluN2C (phospho S1096) antibody
    See all GluN2C primary antibodies
  • Description

    Rabbit polyclonal to GluN2C (phospho S1096)
  • Host species

    Rabbit
  • Specificity

    Specific for the GluN2C subunit of the NMDA receptor phosphorylated at Ser1096. Immunolabeling is blocked by preadsorption of antibody with the phospho-peptide that was used to generate the antibody but not by the corresponding dephospho-peptide.
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat
    Predicted to work with: Cow, Dog, Human, Non human primates
  • Immunogen

    Synthetic peptide corresponding to Rat GluN2C (C terminal) (phospho S1096).
    Database link: Q00961

  • Positive control

    • Mouse brain lysate
  • General notes

    Previously labelled as NMDAR2C. 

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • Storage buffer

    pH: 7.50
    Constituents: 0.01% BSA, 50% Glycerol, 0.87% Sodium chloride, 0.238% HEPES
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Purification notes

    Prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephosphopeptide affinity columns.
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab106569 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 135 kDa.

Target

  • Function

    NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine.
  • Tissue specificity

    Mainly expressed in brain with predominant expression is in the cerebellum, also present in the hippocampus, amygdala, caudate nucleus, corpus callosum, subthalamic nuclei and thalamus. Detected in the heart, skeletal muscle and pancreas.
  • Sequence similarities

    Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2C/GRIN2C subfamily.
  • Cellular localization

    Cell membrane. Cell junction, synapse, postsynaptic cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • GluN2C antibody
    • Glutamate [NMDA] receptor subunit epsilon-3 antibody
    • Glutamate Receptor Ionotropic N Methyl D Aspartate 2C antibody
    • Glutamate receptor ionotropic, NMDA 2C antibody
    • Glutamate receptor, ionotropic, N methyl D aspartate 2C antibody
    • Grin2c antibody
    • N Methly D Aspartate Receptor Channel Subunit Epsilon 3 antibody
    • N Methyl D Aspartate Receptor Subtype 2C antibody
    • N methyl D aspartate receptor subunit 2C antibody
    • N-methyl D-aspartate receptor subtype 2C antibody
    • NMDAR2C antibody
    • NMDE3_HUMAN antibody
    • NR2C antibody
    • OTTHUMP00000041930 antibody
    see all

Images

  • All lanes : Anti-GluN2C (phospho S1096) antibody (ab106569) at 1/1000 dilution

    Lane 1 : Mouse brain lysate
    Lane 2 : Mouse brain lysate with immunoreactivity blocked by preadsorption with the phospho-peptide

    Predicted band size: 135 kDa

References

This product has been referenced in:

  • Chen BS & Roche KW Growth factor-dependent trafficking of cerebellar NMDA receptors via protein kinase B/Akt phosphorylation of NR2C. Neuron 62:471-8 (2009). Read more (PubMed: 19477150) »
See 1 Publication for this product

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