Anti-Glutamate Transporter 1 antibody (ab106289)
Key features and details
- Rabbit polyclonal to Glutamate Transporter 1
- Suitable for: WB
- Reacts with: Mouse, Rat
- Isotype: IgG
Get better batch-to-batch reproducibility with a recombinant antibody
- Research with confidence – consistent and reproducible results with every batch
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- Success from the first experiment – confirmed specificity through extensive validation
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Overview
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Product name
Anti-Glutamate Transporter 1 antibody -
Description
Rabbit polyclonal to Glutamate Transporter 1 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Mouse, Rat
Predicted to work with: Human -
Immunogen
Synthetic peptide corresponding to Rat Glutamate Transporter 1 (C terminal). A 16 residue synthetic peptide derived from the C terminal domain of Rat glutamate transporter 1.
Database link: P31596 -
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Avoid freeze / thaw cycle. -
Storage buffer
Constituent: Whole serum -
Concentration information loading...
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Purity
Whole antiserum -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab106289 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
WB |
1/200 - 1/5000. Predicted molecular weight: 62 kDa.
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Notes |
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WB
1/200 - 1/5000. Predicted molecular weight: 62 kDa. |
Target
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Function
Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. -
Sequence similarities
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A2 subfamily. -
Post-translational
modificationsGlycosylated.
Palmitoylation at Cys-38 is not required for correct subcellular localization, but is important for glutamate uptake activity. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 6506 Human
- Entrez Gene: 20511 Mouse
- Entrez Gene: 29482 Rat
- Omim: 600300 Human
- SwissProt: P43004 Human
- SwissProt: P43006 Mouse
- SwissProt: P31596 Rat
- Unigene: 502338 Human
see all -
Alternative names
- EAA2_HUMAN antibody
- EAAT2 antibody
- Excitatory amino acid transporter 2 antibody
see all
Images
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All lanes : Anti-Glutamate Transporter 1 antibody (ab106289) at 1/1000 dilution
Lane 1 : Protein extract from rat brain
Lane 2 : Protein extract from mouse brain
Predicted band size: 62 kDa
Lane 3 shows inhibition of the immunoreactivity of ab106289 with blocking peptide.
Glutamate Transporter 1 protein is detected at 35 kDa and 70 kDa as a dimer.
Datasheets and documents
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Datasheet download
References (11)
ab106289 has been referenced in 11 publications.
- Postnikova TY et al. Delayed Impairment of Hippocampal Synaptic Plasticity after Pentylenetetrazole-Induced Seizures in Young Rats. Int J Mol Sci 23:N/A (2022). PubMed: 36362260
- Sanches E et al. Dose-Dependent Neuroprotective Effects of Bovine Lactoferrin Following Neonatal Hypoxia-Ischemia in the Immature Rat Brain. Nutrients 13:N/A (2021). PubMed: 34836132
- Yan M et al. Ginkgo biloba extract protects diabetic rats against cerebral ischemia-reperfusion injury by suppressing oxidative stress and upregulating the expression of glutamate transporter 1. Mol Med Rep 21:1809-1818 (2020). PubMed: 32319622
- Lu Y et al. Neuron-Derived Estrogen Is Critical for Astrocyte Activation and Neuroprotection of the Ischemic Brain. J Neurosci 40:7355-7374 (2020). PubMed: 32817249
- Wang J et al. Astrocyte-Derived Estrogen Regulates Reactive Astrogliosis and is Neuroprotective following Ischemic Brain Injury. J Neurosci 40:9751-9771 (2020). PubMed: 33158962