Anti-Glutamine Synthetase antibody [6/Glutamine Synthetase] (ab125724)

Overview

  • Product name
    Anti-Glutamine Synthetase antibody [6/Glutamine Synthetase]
    See all Glutamine Synthetase primary antibodies
  • Description
    Mouse monoclonal [6/Glutamine Synthetase] to Glutamine Synthetase
  • Host species
    Mouse
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Sheep
  • Immunogen

    Full length protein, corresponding to amino acids 1-373 of Sheep Glutamine Synthetase.

  • Positive control
    • Human liver tissue; Human Hepatocellular carcinoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab125724 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/150 - 1/250. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function
    This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts.
  • Involvement in disease
    Defects in GLUL are the cause of congenital systemic glutamine deficiency (CSGD) [MIM:610015]. CSGD is a rare developmental disorder with severe brain malformation resulting in multi-organ failure and neonatal death. Glutamine is largely absent from affected patients serum, urine and cerebrospinal fluid.
  • Sequence similarities
    Belongs to the glutamine synthetase family.
  • Developmental stage
    Expressed during early fetal stages.
  • Cellular localization
    Cytoplasm. Mitochondrion.
  • Information by UniProt
  • Database links
  • Alternative names
    • cell proliferation-inducing protein 59 antibody
    • GLNA antibody
    • GLNA_HUMAN antibody
    • GLNS antibody
    • GLUL antibody
    • Glutamate ammonia ligase antibody
    • Glutamate decarboxylase antibody
    • Glutamate--ammonia ligase antibody
    • glutamine synthase antibody
    • Glutamine synthetase antibody
    • GS antibody
    • PIG 43 antibody
    • PIG 59 antibody
    • PIG43 antibody
    • PIG59 antibody
    • Proliferation inducing protein 43 antibody
    see all

Images

  • ab125724 at 1/150 dilution staining Glutamine Synthetase in Paraffin-embedded Human liver tissue by Immunohistochemistry.

References

This product has been referenced in:
  • Todd L  et al. Jak/Stat signaling regulates the proliferation and neurogenic potential of Müller glia-derived progenitor cells in the avian retina. Sci Rep 6:35703 (2016). Read more (PubMed: 27759082) »
  • Todd L  et al. Heparin-binding EGF-like growth factor (HB-EGF) stimulates the proliferation of Müller glia-derived progenitor cells in avian and murine retinas. Mol Cell Neurosci 69:54-64 (2015). Read more (PubMed: 26500021) »
See all 2 Publications for this product

Customer reviews and Q&As

Answer

Gracias por contactarnos.

He llevado a cabo una búsqueda con los requisitos indicados, y me temo que no hay en el catálogo ningún anticuerpo que cumpla con todos ellos.

Sin embargo, existen otras alternativas contra Glutamine Synthetase, validados mediante IHC-P, producidos en ratón, y que a pesar de que no se han testado en conejo, por similitud de secuencias os pueden interesar.

Si queréis echarle un vistazo a las datasheets, y si os interesa, y queréis participar en el sistema de evaluación de anticuerpos, estaré encantada de facilitaros toda la información.

https://www.abcam.com/Glutamine-Synthetase-antibody-ab64613.html

https://www.abcam.com/Glutamine-Synthetase-antibody-6Glutamine-Synthetase-ab125724.html

Espero que esta información sea de utilidad, en caso contrario, por favor, no dudes en volver a contactarme.

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