Anti-Glutamine Synthetase antibody [6/Glutamine Synthetase] (ab125724)


  • Product name

    Anti-Glutamine Synthetase antibody [6/Glutamine Synthetase]
    See all Glutamine Synthetase primary antibodies
  • Description

    Mouse monoclonal [6/Glutamine Synthetase] to Glutamine Synthetase
  • Host species

  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Sheep
  • Immunogen

    Full length protein, corresponding to amino acids 1-373 of Sheep Glutamine Synthetase.

  • Positive control

    • Human liver tissue; Human Hepatocellular carcinoma tissue.



Our Abpromise guarantee covers the use of ab125724 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/150 - 1/250. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.


  • Function

    This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts.
  • Involvement in disease

    Defects in GLUL are the cause of congenital systemic glutamine deficiency (CSGD) [MIM:610015]. CSGD is a rare developmental disorder with severe brain malformation resulting in multi-organ failure and neonatal death. Glutamine is largely absent from affected patients serum, urine and cerebrospinal fluid.
  • Sequence similarities

    Belongs to the glutamine synthetase family.
  • Developmental stage

    Expressed during early fetal stages.
  • Cellular localization

    Cytoplasm. Mitochondrion.
  • Information by UniProt
  • Database links

  • Alternative names

    • cell proliferation-inducing protein 59 antibody
    • Cgl2214 antibody
    • GLNA antibody
    • GLNA_HUMAN antibody
    • GLNS antibody
    • GLUL antibody
    • Glutamate ammonia ligase antibody
    • Glutamate decarboxylase antibody
    • Glutamate--ammonia ligase antibody
    • glutamine synthase antibody
    • Glutamine synthetase antibody
    • glutamine synthetase I antibody
    • GS antibody
    • PIG 43 antibody
    • PIG 59 antibody
    • PIG43 antibody
    • PIG59 antibody
    • Proliferation inducing protein 43 antibody
    see all


  • ab125724 at 1/150 dilution staining Glutamine Synthetase in Paraffin-embedded Human liver tissue by Immunohistochemistry.


This product has been referenced in:

  • Todd L  et al. Jak/Stat signaling regulates the proliferation and neurogenic potential of Müller glia-derived progenitor cells in the avian retina. Sci Rep 6:35703 (2016). Read more (PubMed: 27759082) »
  • Todd L  et al. Heparin-binding EGF-like growth factor (HB-EGF) stimulates the proliferation of Müller glia-derived progenitor cells in avian and murine retinas. Mol Cell Neurosci 69:54-64 (2015). Read more (PubMed: 26500021) »
See all 2 Publications for this product

Customer reviews and Q&As


Gracias por contactarnos.

He llevado a cabo una búsqueda con los requisitos indicados, y me temo que no hay en el catálogo ningún anticuerpo que cumpla con todos ellos.

Sin embargo, existen otras alternativas contra Glutamine Synthetase, validados mediante IHC-P, producidos en ratón, y que a pesar de que no se han testado en conejo, por similitud de secuencias os pueden interesar.

Si queréis echarle un vistazo a las datasheets, y si os interesa, y queréis participar en el sistema de evaluación de anticuerpos, estaré encantada de facilitaros toda la información.

Espero que esta información sea de utilidad, en caso contrario, por favor, no dudes en volver a contactarme.

Read More

For licensing inquiries, please contact

Sign up