Key features and details
- Rabbit polyclonal to Glutaminyl cyclase
- Suitable for: IHC-P, WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Glutaminyl cyclase antibody
DescriptionRabbit polyclonal to Glutaminyl cyclase
Tested applicationsSuitable for: IHC-P, WBmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Cow
Recombinant fragment corresponding to Human Glutaminyl cyclase aa 162-330.
VPCAMMLELARALDKQLFSLKNISDSRPDLSLQLIFFDGEEAFHLWSPQD SLYGSRHLASKMASTPHPPGARDTNQLHGMDLLVLLDLIGAPFPTFPNFF PNTARWFGRLEAIEHGLREL GLLKDHSSERWYFRNYGYGGVIQDDHIPFLRRGVPVLHLISSPFPEVWH
Database link: Q16769
- HepG2 and Jurkat cell line lysate. Human thyroid tissue.
Previously labelled as QPCT.
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
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FormLyophilized:Reconstitute in 200 uL sterile distilled water
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 98% PBS, 1% BSA
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab201172 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/100 - 1/500.|
|WB||1/200 - 1/1000. Predicted molecular weight: 41 kDa.|
FunctionResponsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.
Sequence similaritiesBelongs to the glutaminyl-peptide cyclotransferase family.
- Information by UniProt
- 5730422A13Rik antibody
- EC antibody
- GCT antibody
Immunohistochemical analysis of formalin fixed, paraffin embedded human thyroid tissue labeling Glutaminyl cyclase with ab201172 at a 1/100 dilution.
All lanes : Anti-Glutaminyl cyclase antibody (ab201172) at 1/500 dilution
Lane 1 : HepG2 cell line lysate
Lane 2 : Jurkat cell line lysate
Predicted band size: 41 kDa
ab201172 has been referenced in 2 publications.
- Wang X et al. Glutaminyl cyclase inhibitor exhibits anti-inflammatory effects in both AD and LPS-induced inflammatory model mice. Int Immunopharmacol 75:105770 (2019). PubMed: 31377588
- Zhao T et al. DNA methylation-regulated QPCT promotes sunitinib resistance by increasing HRAS stability in renal cell carcinoma. Theranostics 9:6175-6190 (2019). PubMed: 31534544