Overview

  • Product name

    Anti-Glutaminyl cyclase antibody
    See all Glutaminyl cyclase primary antibodies
  • Description

    Rabbit polyclonal to Glutaminyl cyclase
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Rat, Sheep, Rabbit, Guinea pig, Cow
  • Immunogen

    Synthetic peptide corresponding to Human Glutaminyl cyclase aa 215-264 (internal sequence).
    Sequence:

    SRHLAAKMAS TPHPPGARGT SQLHGMDLLV LLDLIGAPNP TFPNFFPNSA


    Database link: NP_036545

  • Positive control

    • Human fetal muscle lysate.
  • General notes

    Previously labelled as QPCT.

Properties

Applications

Our Abpromise guarantee covers the use of ab85183 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 38 kDa (predicted molecular weight: 38 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • Function

    Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.
  • Sequence similarities

    Belongs to the glutaminyl-peptide cyclotransferase family.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • 5730422A13Rik antibody
    • EC antibody
    • GCT antibody
    • Glutaminyl cyclase antibody
    • Glutaminyl peptide cyclotransferase antibody
    • Glutaminyl tRNA cyclotransferase antibody
    • Glutaminyl-peptide cyclotransferase antibody
    • Glutaminyl-tRNA cyclotransferase antibody
    • Glutamyl cyclase antibody
    • QC antibody
    • qpct antibody
    • QPCT_HUMAN antibody
    • sQC antibody
    see all

Images

  • Anti-Glutaminyl cyclase antibody (ab85183) at 1 µg/ml + Human fetal muscle lysate at 10 µg

    Secondary
    anti-Rabbit IgG HRP at 1/50000 dilution

    Predicted band size: 38 kDa
    Observed band size: 38 kDa

References

ab85183 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab85183.
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