Anti-Glutathione Peroxidase 1 antibody (ab22604)

Knockout Tested Rabbit polyclonal Glutathione Peroxidase 1 antibody. Validated in WB, IHC, ICC/IF and tested in Mouse, Rat, Cow, Human. Cited in 73 publication(s). Independently reviewed in 23 review(s).

Publishing research using ab22604? Please let us know so that we can cite the reference in this datasheet.

ab22604 has been referenced in 81 publications.

  • Yeo D  et al. Intensified mitophagy in skeletal muscle with aging is downregulated by PGC-1alpha overexpression in vivo. Free Radic Biol Med 130:361-368 (2019). PubMed: 30395971
  • Katamune C  et al. Mutation of the gene encoding the circadian clock component PERIOD2 in oncogenic cells confers chemoresistance by up-regulating the Aldh3a1 gene. J Biol Chem 294:547-558 (2019). PubMed: 30429219
  • Li J & Zheng J Theaflavins prevent cartilage degeneration via AKT/FOXO3 signaling in vitro. Mol Med Rep 19:821-830 (2019). PubMed: 30569095
  • Asai R  et al. CD44 standard isoform is involved in maintenance of cancer stem cells of a hepatocellular carcinoma cell line. Cancer Med 8:773-782 (2019). PubMed: 30636370
  • Peng G  et al. Glutathione peroxidase 4 maintains a stemness phenotype, oxidative homeostasis and regulates biological processes in Panc-1 cancer stem-like cells. Oncol Rep 41:1264-1274 (2019). PubMed: 30535490
  • Gonzalez-Candia A  et al. Antenatal melatonin modulates an enhanced antioxidant/pro-oxidant ratio in pulmonary hypertensive newborn sheep. Redox Biol 22:101128 (2019). PubMed: 30771751
  • Basnet H  et al. Flura-seq identifies organ-specific metabolic adaptations during early metastatic colonization. Elife 8:N/A (2019). PubMed: 30912515
  • Mita Y  et al. Distribution of oxidized DJ-1 in Parkinson's disease-related sites in the brain and in the peripheral tissues: effects of aging and a neurotoxin. Sci Rep 8:12056 (2018). PubMed: 30104666
  • Gao J  et al. Trilobatin Protects Against Oxidative Injury in Neuronal PC12 Cells Through Regulating Mitochondrial ROS Homeostasis Mediated by AMPK/Nrf2/Sirt3 Signaling Pathway. Front Mol Neurosci 11:267 (2018). PubMed: 30104959
  • Fang G  et al. Oxidative status of cardinal ligament in pelvic organ prolapse. Exp Ther Med 16:3293-3302 (2018). PubMed: 30250520
  • Ekoue DN  et al. GPX1 Localizes to the Nucleus in Prostate Epithelium and its Levels are not Associated with Prostate Cancer Recurrence. Antioxidants (Basel) 7:N/A (2018). PubMed: 30453672
  • Romanello KS  et al. Global analysis of erythroid cells redox status reveals the involvement of Prdx1 and Prdx2 in the severity of beta thalassemia. PLoS One 13:e0208316 (2018). PubMed: 30521599
  • Tian X  et al. Protective Role of Nuclear Factor-Erythroid 2-Related Factor 2 Against Radiation-Induced Lung Injury and Inflammation. Front Oncol 8:542 (2018). PubMed: 30533397
  • Meng Q  et al. GPx1 is involved in the induction of protective autophagy in pancreatic cancer cells in response to glucose deprivation. Cell Death Dis 9:1187 (2018). PubMed: 30538220
  • Rodger EJ  et al. Proteomic Analysis of Liver from Human Lipoprotein(a) Transgenic Mice Shows an Oxidative Stress and Lipid Export Response. Biomed Res Int 2018:4963942 (2018). PubMed: 30596094
  • Aguilar M  et al. Mechanisms of Cardiovascular Protection Associated with Intermittent Hypobaric Hypoxia Exposure in a Rat Model: Role of Oxidative Stress. Int J Mol Sci 19:N/A (2018). PubMed: 29373484
  • Orešcanin-Dušic Z  et al. The Effects of Ibogaine on Uterine Smooth Muscle Contractions: Relation to the Activity of Antioxidant Enzymes. Oxid Med Cell Longev 2018:5969486 (2018). PubMed: 29599898
  • Chan JKW  et al. Nordihydroguaiaretic Acid, a Lignan from Larrea tridentata (Creosote Bush), Protects Against American Lifestyle-Induced Obesity Syndrome Diet-Induced Metabolic Dysfunction in Mice. J Pharmacol Exp Ther 365:281-290 (2018). PubMed: 29472517
  • Binte Hossain KF  et al. Inhibitory effects of selenium on cadmium-induced cytotoxicity in PC12 cells via regulating oxidative stress and apoptosis. Food Chem Toxicol 114:180-189 (2018). PubMed: 29454865
  • Vega-Torres JD  et al. Exposure to an obesogenic diet during adolescence leads to abnormal maturation of neural and behavioral substrates underpinning fear and anxiety. Brain Behav Immun 70:96-117 (2018). WB . PubMed: 29428401
  • Kemp KC  et al. Bone marrow transplantation stimulates neural repair in Friedreich's ataxia mice. Ann Neurol 83:779-793 (2018). PubMed: 29534309
  • Stein CS  et al. Mitoregulin: A lncRNA-Encoded Microprotein that Supports Mitochondrial Supercomplexes and Respiratory Efficiency. Cell Rep 23:3710-3720.e8 (2018). PubMed: 29949756
  • Shanmugam G  et al. Chronic Endurance Exercise Impairs Cardiac Structure and Function in Middle-Aged Mice with Impaired Nrf2 Signaling. Front Physiol 8:268 (2017). PubMed: 28515695
  • Oancea-Castillo LR  et al. Comparative analysis of the effects of a sphingosine kinase inhibitor to temozolomide and radiation treatment on glioblastoma cell lines. Cancer Biol Ther 18:400-406 (2017). PubMed: 28494176
  • Wu NC  et al. Intravenous superoxide dismutase as a protective agent to prevent impairment of lung function induced by high tidal volume ventilation. BMC Pulm Med 17:105 (2017). PubMed: 28747201
  • Mita Y  et al. Selenoprotein P-neutralizing antibodies improve insulin secretion and glucose sensitivity in type 2 diabetes mouse models. Nat Commun 8:1658 (2017). PubMed: 29162828
  • Eder K  et al. An excess dietary vitamin E concentration does not influence Nrf2 signaling in the liver of rats fed either soybean oil or salmon oil. Nutr Metab (Lond) 14:71 (2017). PubMed: 29176993
  • Tang J  et al. Mechanism of Mechanical Trauma-Induced Extracellular Matrix Remodeling of Fibroblasts in Association with Nrf2/ARE Signaling Suppression Mediating TGF-ß1/Smad3 Signaling Inhibition. Oxid Med Cell Longev 2017:8524353 (2017). PubMed: 29109834
  • Aubdool AA  et al. A Novel a-Calcitonin Gene-Related Peptide Analogue Protects Against End-Organ Damage in Experimental Hypertension, Cardiac Hypertrophy, and Heart Failure. Circulation 136:367-383 (2017). PubMed: 28446517
  • Li M  et al. Loss of selenocysteine insertion sequence binding protein 2 suppresses the proliferation, migration/invasion and hormone secretion of human trophoblast cells via the PI3K/Akt and ERK signaling pathway. Placenta 55:81-89 (2017). PubMed: 28623977
  • Magierowski M  et al. Nitric oxide, afferent sensory nerves, and antioxidative enzymes in the mechanism of protection mediated by tricarbonyldichlororuthenium(II) dimer and sodium hydrosulfide against aspirin-induced gastric damage. J Gastroenterol N/A:N/A (2017). PubMed: 28238019
  • Tang J  et al. Potential therapeutic role of punicalagin against mechanical-trauma-induced stress urinary incontinence via upregulation of Nrf2 and TGF-ß1 signaling : Effect of punicalagin on mechanical trauma induced SUI. Int Urogynecol J 28:947-955 (2017). PubMed: 28168411
  • Dubey A & Copeland PR The Selenocysteine-Specific Elongation Factor Contains Unique Sequences That Are Required for Both Nuclear Export and Selenocysteine Incorporation. PLoS One 11:e0165642 (2016). WB ; Human . PubMed: 27802322
  • Lee WH  et al. Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies. Elife 5:N/A (2016). WB ; Mouse . PubMed: 27863209
  • Kemp KC  et al. Cytokine therapy-mediated neuroprotection in a Friedreich's ataxia mouse model. Ann Neurol N/A:N/A (2016). WB ; Mouse . PubMed: 28009062
  • Crilly MJ  et al. The role of Nrf2 in skeletal muscle contractile and mitochondrial function. J Appl Physiol (1985) 121:730-40 (2016). PubMed: 27471236
  • Polhemus DJ  et al. Radiofrequency Renal Denervation Protects the Ischemic Heart via Inhibition of GRK2 and Increased Nitric Oxide Signaling. Circ Res 119:470-80 (2016). PubMed: 27296507
  • Shanmugam G  et al. A biphasic effect of TNF-a in regulation of the Keap1/Nrf2 pathway in cardiomyocytes. Redox Biol 9:77-89 (2016). PubMed: 27423013
  • Li BS  et al. Role of mechanical strain-activated PI3K/Akt signaling pathway in pelvic organ prolapse. Mol Med Rep 14:243-53 (2016). WB ; Human . PubMed: 27176043
  • Wawrzyniak NR  et al. Idiopathic chronic fatigue in older adults is linked to impaired mitochondrial content and biogenesis signaling in skeletal muscle. Oncotarget 7:52695-52709 (2016). PubMed: 27447862
  • Tweedie D  et al. Cognitive Impairments Induced by Concussive Mild Traumatic Brain Injury in Mouse Are Ameliorated by Treatment with Phenserine via Multiple Non-Cholinergic and Cholinergic Mechanisms. PLoS One 11:e0156493 (2016). PubMed: 27254111
  • Ye T  et al. Green tea polyphenol (-)-epigallocatechin-3-gallate restores Nrf2 activity and ameliorates crescentic glomerulonephritis. PLoS One 10:e0119543 (2015). WB . PubMed: 25785827
  • Herrera EA  et al. O3 Supplementation and intermittent hypobaric hypoxia induce cardioprotection enhancing antioxidant mechanisms in adult rats. Mar Drugs 13:838-60 (2015). PubMed: 25658050
  • Ristic AJ  et al. Hippocampal antioxidative system in mesial temporal lobe epilepsy. Epilepsia 56:789-99 (2015). PubMed: 25864570
  • Di Filippo C  et al. Daily Oxygen/O3 Treatment Reduces Muscular Fatigue and Improves Cardiac Performance in Rats Subjected to Prolonged High Intensity Physical Exercise. Oxid Med Cell Longev 2015:190640 (2015). WB ; Rat . PubMed: 26265981
  • Moghimi E  et al. Dietary Vitamin D3 Restriction Exacerbates Disease Pathophysiology in the Spinal Cord of the G93A Mouse Model of Amyotrophic Lateral Sclerosis. PLoS One 10:e0126355 (2015). WB ; Mouse . PubMed: 26020962
  • Xiong W  et al. NRF2 promotes neuronal survival in neurodegeneration and acute nerve damage. J Clin Invest 125:1433-45 (2015). IHC-Fr ; Mouse . PubMed: 25798616
  • Kang C  et al. PGC-1a overexpression by in vivo transfection attenuates mitochondrial deterioration of skeletal muscle caused by immobilization. FASEB J 29:4092-106 (2015). WB ; Mouse . PubMed: 26178167
  • Moura CS  et al. Whey protein hydrolysate enhances HSP90 but does not alter HSP60 and HSP25 in skeletal muscle of rats. PLoS One 9:e83437 (2014). WB ; Rat . PubMed: 24465380
  • Wolff G  et al. Exercise modulates redox-sensitive small GTPase activity in the brain microvasculature in a model of brain metastasis formation. PLoS One 9:e97033 (2014). WB ; Mouse . PubMed: 24804765
  • Peng S  et al. In Barrett's esophagus patients and Barrett's cell lines, ursodeoxycholic acid increases antioxidant expression and prevents DNA damage by bile acids. Am J Physiol Gastrointest Liver Physiol 307:G129-39 (2014). WB ; Human . PubMed: 24852569
  • Seeher S  et al. Secisbp2 is essential for embryonic development and enhances selenoprotein expression. Antioxid Redox Signal 21:835-49 (2014). WB ; Mouse . PubMed: 24274065
  • Plomaritas DR  et al. Chronic hypoxia limits H2O2-induced inhibition of ASIC1-dependent store-operated calcium entry in pulmonary arterial smooth muscle. Am J Physiol Lung Cell Mol Physiol 307:L419-30 (2014). PubMed: 24993130
  • Agbor TA  et al. The oxido-reductase enzyme glutathione peroxidase 4 (GPX4) governs Salmonella Typhimurium-induced neutrophil transepithelial migration. Cell Microbiol 16:1339-53 (2014). PubMed: 24617613
  • Cumming KT  et al. Effects of vitamin C and E supplementation on endogenous antioxidant systems and heat shock proteins in response to endurance training. Physiol Rep 2:N/A (2014). WB ; Human . PubMed: 25293598
  • Dalmases M  et al. Brain tissue hypoxia and oxidative stress induced by obstructive apneas is different in young and aged rats. Sleep 37:1249-56 (2014). PubMed: 25061253
  • Sindler AL  et al. Age and exercise training alter signaling through reactive oxygen species in the endothelium of skeletal muscle arterioles. J Appl Physiol 114:681-93 (2013). WB ; Rat . PubMed: 23288555
  • Assalin HB  et al. Impact of the length of vitamin D deficiency on cardiac remodeling. Circ Heart Fail 6:809-16 (2013). PubMed: 23709660
  • Lanoix D  et al. Melatonin: The watchdog of villous trophoblast homeostasis against hypoxia/reoxygenation-induced oxidative stress and apoptosis. Mol Cell Endocrinol 381:35-45 (2013). PubMed: 23886990
  • Yuki K  et al. Neuroprotective role of superoxide dismutase 1 in retinal ganglion cells and inner nuclear layer cells against N-methyl-d-aspartate-induced cytotoxicity. Exp Eye Res 115C:230-238 (2013). PubMed: 23856406
  • Wang Y  et al. Piperlongumine induces autophagy by targeting p38 signaling. Cell Death Dis 4:e824 (2013). Human . PubMed: 24091667
  • Brioche T  et al. Growth Hormone Replacement Therapy Prevents Sarcopenia by a Dual Mechanism: Improvement of Protein Balance and of Antioxidant Defenses. J Gerontol A Biol Sci Med Sci N/A:N/A (2013). Rat . PubMed: 24300031
  • Kumar A  et al. Influence of late-life exposure to environmental enrichment or exercise on hippocampal function and CA1 senescent physiology. Neurobiol Aging 33:828.e1-17 (2012). WB . PubMed: 21820213
  • Patrushev N  et al. Angiotensin II requires zinc and downregulation of the zinc transporters ZnT3 and ZnT10 to induce senescence of vascular smooth muscle cells. PLoS One 7:e33211 (2012). WB ; Rat . PubMed: 22427991
  • Hudson TS  et al. Selenoproteins reduce susceptibility to DMBA-induced mammary carcinogenesis. Carcinogenesis : (2012). WB . PubMed: 22436612
  • Peng A  et al. The green tea polyphenol (-)-epigallocatechin-3-gallate ameliorates experimental immune-mediated glomerulonephritis. Kidney Int 80:601-11 (2011). WB ; Mouse . PubMed: 21544063
  • O'Dwyer D  et al. The proteomics of colorectal cancer: identification of a protein signature associated with prognosis. PLoS One 6:e27718 (2011). PubMed: 22125622
  • Ungvari Z  et al. Adaptive induction of NF-E2-related factor-2-driven antioxidant genes in endothelial cells in response to hyperglycemia. Am J Physiol Heart Circ Physiol 300:H1133-40 (2011). PubMed: 21217061
  • Siu PM  et al. Habitual exercise increases resistance of lymphocytes to oxidant-induced DNA damage by upregulating expression of antioxidant and DNA repairing enzymes. Exp Physiol 96:889-906 (2011). WB . PubMed: 21622964
  • Roland-Zejly L  et al. Altered placental glutathione peroxidase mRNA expression in preeclampsia according to the presence or absence of labor. Placenta 32:161-7 (2011). PubMed: 21145108
  • Wirth EK  et al. Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration. FASEB J 24:844-52 (2010). WB ; Mouse . PubMed: 19890015
  • Prigione A  et al. The senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells. Stem Cells 28:721-33 (2010). WB ; Human . PubMed: 20201066
  • Miniard AC  et al. Nucleolin binds to a subset of selenoprotein mRNAs and regulates their expression. Nucleic Acids Res 38:4807-20 (2010). WB ; Rat . PubMed: 20385601
  • Safdar A  et al. Dysfunctional Nrf2-Keap1 redox signaling in skeletal muscle of the sedentary old. Free Radic Biol Med 49:1487-93 (2010). WB ; Human . PubMed: 20708680
  • Kavazis AN  et al. Short-term exercise training protects against doxorubicin-induced cardiac mitochondrial damage independent of HSP72. Am J Physiol Heart Circ Physiol 299:H1515-24 (2010). PubMed: 20833957
  • Brink TC  et al. Age-related transcriptional changes in gene expression in different organs of mice support the metabolic stability theory of aging. Biogerontology 10:549-64 (2009). WB ; Mouse . PubMed: 19031007
  • Kromer A & Moosmann B Statin-induced liver injury involves cross-talk between cholesterol and selenoprotein biosynthetic pathways. Mol Pharmacol 75:1421-9 (2009). PubMed: 19332511
  • Kavazis AN  et al. Mechanical ventilation induces diaphragmatic mitochondrial dysfunction and increased oxidant production. Free Radic Biol Med 46:842-50 (2009). PubMed: 19185055
  • Bruin JE  et al. Maternal nicotine exposure increases oxidative stress in the offspring. Free Radic Biol Med 44:1919-25 (2008). WB ; Rat . PubMed: 18343235
  • Seiler A  et al. Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death. Cell Metab 8:237-48 (2008). PubMed: 18762024
  • Shan G  et al. Increase in Blood Glutathione and Erythrocyte Proteins Related to Glutathione Generation, Reduction and Utilization in African-American Old Women with Diabetes. J Sci Technol Environ 5:N/A (0). PubMed: 26770888

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