Overview

  • Product name

    Anti-Glutathione Peroxidase 2/GPX2 antibody
    See all Glutathione Peroxidase 2/GPX2 primary antibodies
  • Description

    Rabbit polyclonal to Glutathione Peroxidase 2/GPX2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Rat, Cow, Dog, Pig, Monkey
  • Immunogen

    Synthetic peptide corresponding to Human Glutathione Peroxidase 2/GPX2 aa 126-190.

  • Positive control

    • Recombinant Human Glutathione Peroxidase 2/GPX2 protein (ab116151) can be used as a positive control in WB. HepG2 whole cell lysate; Human gastric carcinoma and Mouse muscle tissues.
  • General notes

     This product was previously labelled as Glutathione Peroxidase 2

     

Properties

Applications

Our Abpromise guarantee covers the use of ab137431 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 22 kDa.
IHC-P 1/100 - 1/1000. Suggested antigen retrieval using heat mediated 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0).

Target

  • Function

    Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors.
  • Tissue specificity

    Mostly in liver and gastrointestinal tract, not found in heart or kidney.
  • Sequence similarities

    Belongs to the glutathione peroxidase family.
  • Cellular localization

    Cytoplasm. Mainly cytoplasmic.
  • Information by UniProt
  • Database links

  • Alternative names

    • Gastrointestinal glutathione peroxidase antibody
    • GI GPx antibody
    • Glutathione peroxidase 2 (gastrointestinal) antibody
    • Glutathione peroxidase 2 antibody
    • Glutathione peroxidase gastrointestinal antibody
    • Glutathione peroxidase related protein 2 antibody
    • Glutathione peroxidase-gastrointestinal antibody
    • Glutathione peroxidase-related protein 2 antibody
    • GPRP antibody
    • GPRP-2 antibody
    • GPx 2 antibody
    • GPx-2 antibody
    • GPx-GI antibody
    • GPX2 antibody
    • GPX2_HUMAN antibody
    • GSHPx 2 antibody
    • GSHPx GI antibody
    • GSHPx-2 antibody
    • GSHPx-GI antibody
    see all

Images

  • Anti-Glutathione Peroxidase 2/GPX2 antibody (ab137431) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

    Predicted band size: 22 kDa



    12% SDS PAGE
  • Immunohistochemical analysis of paraffin-embedded Human gastric carcinoma tissue labelling Glutathione Peroxidase 2/GPX2 with ab137431 at 1/500 dilution.

  • Immunohistochemical analysis of paraffin-embedded Mouse muscle tissue labelling Glutathione Peroxidase 2/GPX2 with ab137431 at 1/500 dilution.

References

This product has been referenced in:

  • Wall SB  et al. Thioredoxin Reductase-1 Inhibition Augments Endogenous Glutathione-Dependent Antioxidant Responses in Experimental Bronchopulmonary Dysplasia. Oxid Med Cell Longev 2019:7945983 (2019). Read more (PubMed: 30805084) »
  • Tindell R  et al. Selenium supplementation of lung epithelial cells enhances nuclear factor E2-related factor 2 (Nrf2) activation following thioredoxin reductase inhibition. Redox Biol 19:331-338 (2018). Read more (PubMed: 30212802) »
See all 5 Publications for this product

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