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    glutathione-reductase-antibody-ab137513.pdf

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Signal Transduction Metabolism Mitochondrial
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Anti-Glutathione Reductase antibody (ab137513)

  • Datasheet
  • SDS
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Western blot - Anti-Glutathione Reductase antibody (ab137513)
  • Western blot - Anti-Glutathione Reductase antibody (ab137513)

Key features and details

  • Rabbit polyclonal to Glutathione Reductase
  • Suitable for: WB
  • Reacts with: Mouse, Human
  • Isotype: IgG

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Secondary
Product image
Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
Protein
Product image
Recombinant human Glutathione Reductase protein (ab82730)

View more associated products

Overview

  • Product name

    Anti-Glutathione Reductase antibody
    See all Glutathione Reductase primary antibodies
  • Description

    Rabbit polyclonal to Glutathione Reductase
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Rat
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 164-403 of Human Glutathione Reductase (UniProt ID: P00390).

  • Positive control

    • A549, HeLa, HepG2, HCT116 and Mouse brain whole cell lysates.
  • General notes

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer

    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol (glycerin, glycerine)
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Signal Transduction
    • Metabolism
    • Mitochondrial
    • Cell Biology
    • Other Antibodies
    • Oxidative Stress
    • Metabolism
    • Pathways and Processes
    • Mitochondrial Metabolism
    • Mitochondrial markers
    • Metabolism
    • Pathways and Processes
    • Redox metabolism
    • Oxidative stress

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
  • Positive Controls

    • HepG2 cytoplasmic extract lysate (ab14659)
    • HeLa whole cell lysate (ab29545)
    • Mouse brain tissue lysate - total protein (ab30151)
    • A549 whole cell lysate (ab7910)
  • Recombinant Protein

    • Recombinant human Glutathione Reductase protein (ab82730)
  • Related Products

    • Recombinant Human Glutathione Reductase protein (ab116160)
    • Recombinant human Glutathione Reductase protein (ab82730)

Applications

Our Abpromise guarantee covers the use of ab137513 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 56 kDa.

Target

  • Function

    Maintains high levels of reduced glutathione in the cytosol.
  • Sequence similarities

    Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
  • Domain

    Each subunit can be divided into 4 domains that are consecutive along the polypeptide chain. Domains 1 and 2 bind FAD and NADPH, respectively. Domain 4 forms the interface.
  • Cellular localization

    Cytoplasm and Mitochondrion.
  • Target information above from: UniProt accession P00390 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 2936 Human
    • Entrez Gene: 14782 Mouse
    • Entrez Gene: 116686 Rat
    • Omim: 138300 Human
    • SwissProt: P00390 Human
    • SwissProt: P47791 Mouse
    • SwissProt: P70619 Rat
    • Unigene: 271510 Human
    • Unigene: 283573 Mouse
    • Unigene: 19721 Rat
    see all
  • Alternative names

    • GLR1 antibody
    • GLUR antibody
    • Glutathione reductase antibody
    • Glutathione reductase mitochondrial antibody
    • Glutathione reductase, mitochondrial antibody
    • GR antibody
    • Gr1 antibody
    • GRase antibody
    • GRD 1 antibody
    • GRD1 antibody
    • GSHR_HUMAN antibody
    • GSR antibody
    • MGC78522 antibody
    see all

Images

  • Western blot - Anti-Glutathione Reductase antibody (ab137513)
    Western blot - Anti-Glutathione Reductase antibody (ab137513)
    Anti-Glutathione Reductase antibody (ab137513) at 1/1000 dilution + Mouse brain whole cell lysate at 50 µg

    Predicted band size: 56 kDa



    10% SDS PAGE
  • Western blot - Anti-Glutathione Reductase antibody (ab137513)
    Western blot - Anti-Glutathione Reductase antibody (ab137513)
    Anti-Glutathione Reductase antibody (ab137513) at 1/1000 dilution + HCT116 whole cell lysate at 30 µg

    Predicted band size: 56 kDa

Protocols

  • Western blot protocols

Click here to view the general protocols

Datasheets and documents

    • Datasheet
    • SDS
  • References (1)

    Publishing research using ab137513? Please let us know so that we can cite the reference in this datasheet.

    ab137513 has been referenced in 1 publication.

    • Gu Y  et al. Involvement of Kruppel-like factor 9 in bleomycin-induced pulmonary toxicity. Mol Med Rep 12:5262-6 (2015). PubMed: 26133229

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