Gly-Phe beta-naphthylamide, Cathepsin C substrate (ab145914)

Overview

  • Product name

    Gly-Phe beta-naphthylamide, Cathepsin C substrate
  • Description

    Cathepsin C substrate
  • Alternative names

    • Gly-L-Phe-2-NNap
    • gly-phe 2-naphthylamide
    • Gly-Phe beta-naphthylamide
    • Gly-phe-naphthylamide
    • glycyl-L-phenylalanine 2-naphthylamide
    • Glycylphenylalanine2-naphthylamide
    • H-Gly-Phe-BNA
    see all
  • Biological description

    Substrate for the lysosomal cysteine protease Cathepsin C. Accumulates within the lysosome. Hydrolysis by cathepsin C degrades Gly-Phe-β-naphthylamide into fragments that do not easily diffuse through the lysosomal membrane, leading to a loss of lysosome membrane integrity. Used to study intralysosomal hydrolysis, lysosomal membrane permeability, and the function of cathepsin C. Inhibits the cathepsin-dependent activation of caspase-8.

  • Purity

    > 95%
  • CAS Number

    21438-66-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Glycylphenylalanine 2-naphthylamide
  • Molecular weight

    347.41
  • Molecular formula

    C21H21N3O2
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Qiu GF  et al. Expression and purification of active recombinant cathepsin C (dipeptidyl aminopeptidase I) of kuruma prawn Marsupenaeus japonicus in insect cells. J Biomed Biotechnol 2009:746289 (2009). Read more (PubMed: 19707514) »
  • Baumgartner HK  et al. Caspase-8-mediated apoptosis induced by oxidative stress is independent of the intrinsic pathway and dependent on cathepsins. Am J Physiol Gastrointest Liver Physiol 293:G296-307 (2007). Read more (PubMed: 17431216) »
  • Doughty MJ & Gruenstein EI Chloride-insensitive, glycine-phenylalanine-naphthylamide hydrolysis at neutral pH in human skin fibroblasts. Biochem Cell Biol 64:772-81 (1986). Read more (PubMed: 3768167) »
  • Jadot M  et al. Intralysosomal hydrolysis of glycyl-L-phenylalanine 2-naphthylamide. Biochem J 219:965-70 (1984). Read more (PubMed: 6743255) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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