Gly-Phe beta-naphthylamide, Cathepsin C substrate (ab145914)

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Chemical Structure - Gly-Phe beta-naphthylamide, Cathepsin C substrate (ab145914)

    Key features and details

    • Cathepsin C substrate
    • CAS Number: 21438-66-4
    • Purity: > 95%
    • Soluble in DMSO
    • Form / State: Solid
    • Source: Synthetic

    Overview

    • Product name

      Gly-Phe beta-naphthylamide, Cathepsin C substrate

    • Description

      Cathepsin C substrate

    • Alternative names

      • Gly-L-Phe-2-NNap
      • gly-phe 2-naphthylamide
      • Gly-Phe beta-naphthylamide
      • Gly-phe-naphthylamide
      • glycyl-L-phenylalanine 2-naphthylamide
      • Glycylphenylalanine2-naphthylamide
      • H-Gly-Phe-BNA
      see all

    • Biological description

      Substrate for the lysosomal cysteine protease Cathepsin C. Accumulates within the lysosome. Hydrolysis by cathepsin C degrades Gly-Phe-β-naphthylamide into fragments that do not easily diffuse through the lysosomal membrane, leading to a loss of lysosome membrane integrity. Used to study intralysosomal hydrolysis, lysosomal membrane permeability, and the function of cathepsin C. Inhibits the cathepsin-dependent activation of caspase-8.

    • Purity

      > 95%

    • CAS Number

      21438-66-4

    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      Glycylphenylalanine 2-naphthylamide

    • Molecular weight

      347.41

    • Molecular formula

      C21H21N3O2

    • Storage instructions

      Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

    • Solubility overview

      Soluble in DMSO

    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • Source

      Synthetic

    Associated products

      Images

      • Chemical Structure - Gly-Phe beta-naphthylamide, Cathepsin C substrate (ab145914)
        Chemical Structure - Gly-Phe beta-naphthylamide, Cathepsin C substrate (ab145914)
        2D chemical structure image of ab145914, Gly-Phe beta-naphthylamide, Cathepsin C substrate

      Protocols

      To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

      Click here to view the general protocols

      References (1)

      Publishing research using ab145914? Please let us know so that we can cite the reference in this datasheet.

      ab145914 has been referenced in 1 publication.

      • Beaulieu-Laroche L & Harnett MT Dendritic Spines Prevent Synaptic Voltage Clamp. Neuron 97:75-82.e3 (2018). PubMed: 29249288

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