Overview

  • Product name

    Anti-Glycine Receptor alpha 3 antibody
    See all Glycine Receptor alpha 3 primary antibodies
  • Description

    Rabbit polyclonal to Glycine Receptor alpha 3
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide, corresponding to a region within amino acids 1-11 of Human Glycine Receptor alpha 3

  • Positive control

    • 293T, A431, H1299, HeLa S3, Molt 4 or Raji lysates
  • General notes

    Keep as concentrated solution.

Properties

Applications

Our Abpromise guarantee covers the use of ab137642 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 54 kDa.

Target

  • Function

    The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).
  • Tissue specificity

    Widely distributed throughout the central nervous system.
  • Sequence similarities

    Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA3 sub-subfamily.
  • Domain

    The N-terminal domain carries structural determinants essential for agonist and antagonist binding. TM2 is thought to form the innert wall of the chloride channel. The cytoplasmic loop is an important determinant of channel inactivation kinetics.
  • Cellular localization

    Cell junction > synapse > postsynaptic cell membrane. Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • GLRA 3 antibody
    • Glra3 antibody
    • GLRA3_HUMAN antibody
    • Glycine receptor alpha 3 polypeptide antibody
    • Glycine receptor alpha 3 subunit antibody
    • Glycine receptor subunit alpha 3 antibody
    • Glycine receptor subunit alpha-3 antibody
    • Ligand gated ion channel antibody
    see all

Images

  • All lanes : Anti-Glycine Receptor alpha 3 antibody (ab137642) at 1/1000 dilution

    Lane 1 : A431 whole cell lysate
    Lane 2 : Raji whole cell lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 54 kDa



    10% SDS PAGE

References

ab137642 has not yet been referenced specifically in any publications.

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