Overview

  • Product name

    Anti-Glycogen synthase 1/GYS1 antibody
    See all Glycogen synthase 1/GYS1 primary antibodies
  • Description

    Rabbit polyclonal to Glycogen synthase 1/GYS1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IP, WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Chimpanzee, Orangutan
  • Immunogen

    Synthetic peptide within Human Glycogen synthase 1/GYS1 aa 625-675. The exact sequence is proprietary.
    Sequence:

    PNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGER Y


    Database link: P13807

  • Positive control

    • HeLa, 293T, Jurkat, TCMK-1, and NIH3T3 whole cell lysates.
  • General notes

     This product was previously labelled as Glycogen synthase 1

     

Properties

Applications

Our Abpromise guarantee covers the use of ab186059 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at 2-10 µg/mg of lysate.
WB 1/2000 - 1/10000. Predicted molecular weight: 84 kDa.

Target

  • Function

    Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.
  • Pathway

    Glycan biosynthesis; glycogen biosynthesis.
  • Involvement in disease

    Defects in GYS1 are the cause of muscle glycogen storage disease type 0 (GSD0b) [MIM:611556]; also known as muscle glycogen synthase deficiency. GSD0b is a metabolic disorder characterized by fasting hypoglycemia presenting in infancy or early childhood. The role of muscle glycogen is to provide critical energy during bursts of activity and sustained muscle work.
  • Sequence similarities

    Belongs to the glycosyltransferase 3 family.
  • Information by UniProt
  • Database links

  • Alternative names

    • Glycogen [starch] synthase antibody
    • Glycogen synthase 1 (muscle) antibody
    • Glycogen synthase 1 antibody
    • GSY antibody
    • GYS antibody
    • Gys1 antibody
    • GYS1_HUMAN antibody
    • muscle antibody
    see all

Images

  • All lanes : Anti-Glycogen synthase 1/GYS1 antibody (ab186059) at 0.1 µg/ml

    Lane 1 : HeLa whole cell lysate
    Lane 2 : 293T whole cell lysate
    Lane 3 : Jurkat whole cell lysate
    Lane 4 : TCMK-1 whole cell lysate
    Lane 5 : NIH3T3 whole cell lysate

    Lysates/proteins at 50 µg per lane.

    Developed using the ECL technique.

    Predicted band size: 84 kDa


    Exposure time: 30 seconds
  • Immunoprecipitation. ab186059 at 1 µg/ml staining Glycogen synthase 1/GYS1 in 293T whole cell lysate immunoprecipitated using ab186059 at 6 µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).
    Lane 2: controle IgG.

References

ab186059 has not yet been referenced specifically in any publications.

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