Overview

  • Product name

    Anti-Glycogen synthase 1/GYS1 antibody
    See all Glycogen synthase 1/GYS1 primary antibodies
  • Description

    Rabbit polyclonal to Glycogen synthase 1/GYS1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-P, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant fragment corresponding to Human Glycogen synthase 1/GYS1.
    Database link: P13807

  • Positive control

    • IHC-P: Human heart tissue. ICC/IF: HeLa cells. WB: HeLa, HEK-293T, BT-474 and mouse heart extract.
  • General notes

     This product was previously labelled as Glycogen synthase 1

     

Properties

Applications

Our Abpromise guarantee covers the use of ab230422 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/20000. Predicted molecular weight: 84 kDa.
IHC-P 1/200.
ICC/IF 1/50 - 1/100.

Target

  • Function

    Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.
  • Pathway

    Glycan biosynthesis; glycogen biosynthesis.
  • Involvement in disease

    Defects in GYS1 are the cause of muscle glycogen storage disease type 0 (GSD0b) [MIM:611556]; also known as muscle glycogen synthase deficiency. GSD0b is a metabolic disorder characterized by fasting hypoglycemia presenting in infancy or early childhood. The role of muscle glycogen is to provide critical energy during bursts of activity and sustained muscle work.
  • Sequence similarities

    Belongs to the glycosyltransferase 3 family.
  • Information by UniProt
  • Database links

  • Alternative names

    • Glycogen [starch] synthase antibody
    • Glycogen synthase 1 (muscle) antibody
    • Glycogen synthase 1 antibody
    • GSY antibody
    • GYS antibody
    • Gys1 antibody
    • GYS1_HUMAN antibody
    • muscle antibody
    see all

Images

  • All lanes : Anti-Glycogen synthase 1/GYS1 antibody (ab230422) at 1/500 dilution

    Lane 1 : HeLa (Human epithelial cell line from cervix adenocarcinoma) cell extracts
    Lane 2 : HEK-293T (Human epithelial cell line from embryonic kidney transformed with large T antigen) cell extracts
    Lane 3 : BT-474 (Human ductal breast epithelial tumor cell line) cell extracts
    Lane 4 : Mouse heart extracts

    Developed using the ECL technique.

    Predicted band size: 84 kDa

  • HeLa (Human epithelial cell line from cervix adenocarcinoma) cells stained for Glycogen synthase 1/GYS1 using ab230422 (green) at a dilution of 1/50 in ICC/IF.

    Nuclear counterstain: DAPI (blue).

  • Formalin-fixed, paraffin-embedded human heart tissue stained for Glycogen synthase 1/GYS1 with ab230422 at a 1/200 dilution in immunohistochemical analysis.

References

ab230422 has not yet been referenced specifically in any publications.

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