Description

Specifications

Our Abpromise guarantee covers the use of ab204860 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Functional Studies

    HPLC

  • Form

    Lyophilised
  • Additional notes

    ab204860 (Glycogen synthase 1/GYS1 peptide) can be utilized as a substrate for the following active protein kinases:

     

    ab60863 (Active human GSK3 beta full length protein)
    ab63193 (Active human GSK3 beta full length protein)

     

     This product was previously labelled as Glycogen synthase 1

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Avoid freeze / thaw cycle.

  • Reconstitution
    Dilute peptide in 25mM Tris-HCl, pH 7.5 solution to a final concentration of 1 mg/ml. For optimal storage, aliquot diluted product into smaller quantities and store at recommended temperature.

General Info

  • Alternative names

    • Glycogen [starch] synthase
    • Glycogen synthase 1
    • Glycogen synthase 1 (muscle)
    • GSY
    • GYS
    • Gys1
    • GYS1_HUMAN
    • muscle
    see all
  • Function

    Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.
  • Pathway

    Glycan biosynthesis; glycogen biosynthesis.
  • Involvement in disease

    Defects in GYS1 are the cause of muscle glycogen storage disease type 0 (GSD0b) [MIM:611556]; also known as muscle glycogen synthase deficiency. GSD0b is a metabolic disorder characterized by fasting hypoglycemia presenting in infancy or early childhood. The role of muscle glycogen is to provide critical energy during bursts of activity and sustained muscle work.
  • Sequence similarities

    Belongs to the glycosyltransferase 3 family.
  • Information by UniProt

References

ab204860 has not yet been referenced specifically in any publications.

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