Anti-Glycoprotein VI antibody - C-terminal (ab175276)

Overview

  • Product name
    Anti-Glycoprotein VI antibody - C-terminal
    See all Glycoprotein VI primary antibodies
  • Description
    Rabbit polyclonal to Glycoprotein VI - C-terminal
  • Host species
    Rabbit
  • Tested applications
    Suitable for: Flow Cyt, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human Glycoprotein VI (C terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: Q9HCN6

  • Positive control
    • K562 cell line lysate and K562 cells.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab175276 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt 1/10 - 1/50.

ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.

 

WB 1/1000. Predicted molecular weight: 37 kDa.

Target

  • Function
    Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2.
  • Tissue specificity
    Megakaryocytes and platelets.
  • Involvement in disease
    Bleeding disorder, platelet-type 11
  • Sequence similarities
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Post-translational
    modifications
    N-linked glycosylation at Asn-92 is not required for the cell surface expression, but contributes to maximal adhesion to type I collagen, collagen-related peptide (CRP), and, to a lesser extent, to the snake venom C-type lectin convulxin (CVX).
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Glycoprotein 6 antibody
    • Glycoprotein VI antibody
    • GP6 antibody
    • GPIV antibody
    • GPVI antibody
    • GPVI_HUMAN antibody
    • MGC138168 antibody
    • Platelet collagen receptor antibody
    • Platelet glycoprotein VI antibody
    • Platelet glycoprotein VI precursor antibody
    see all

Images

  • Flow cytometric analysis of K562 cells (right histogram) labeling Glycoprotein VI  with ab175276 at 1/10 dilution compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis

  • Anti-Glycoprotein VI antibody - C-terminal (ab175276) at 1/1000 dilution + K562 cell line lysate at 15 µg

    Developed using the ECL technique.

    Predicted band size: 37 kDa

References

ab175276 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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