Overview

  • Product name
    Anti-GLYR1 antibody [EPR10077(B)]
    See all GLYR1 primary antibodies
  • Description
    Rabbit monoclonal [EPR10077(B)] to GLYR1
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IHC-Pmore details
    Unsuitable for: Flow Cyt,ICC/IF or IP
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human GLYR1. The exact sequence is proprietary.

  • Positive control
    • Jurkat, HeLa and K562 cell lysates. Human colon tissue.
  • General notes

     

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab167155 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 61 kDa.
IHC-P 1/50 - 1/100.
  • Application notes
    Is unsuitable for Flow Cyt,ICC/IF or IP.
  • Target

    • Function
      May have oxidoreductase activity. Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6. Recruited on chromatin, recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3).
    • Sequence similarities
      Belongs to the 3-hydroxyisobutyrate dehydrogenase family. NP60 subfamily.
      Contains 1 A.T hook DNA-binding domain.
      Contains 1 PWWP domain.
    • Domain
      The A.T hook DNA-binding domain is required for the interaction with MAPK14.
      The PWWP domain probably mediates the binding to H3K36me3.
    • Cellular localization
      Nucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • 3 hydroxyisobutyrate dehydrogenase like protein antibody
      • 3-hydroxyisobutyrate dehydrogenase-like protein antibody
      • BM045 antibody
      • Cytokine like nuclear factor n pac antibody
      • Cytokine-like nuclear factor N-PAC antibody
      • Glyoxylate reductase 1 homolog antibody
      • GLYR1 antibody
      • GLYR1_HUMAN antibody
      • HIBDL antibody
      • N-PAC antibody
      • NP60 antibody
      • Nuclear protein 60 kDa antibody
      • Nuclear protein NP60 antibody
      • Nuclear protein of 60 kDa antibody
      • Putative oxidoreductase GLYR1 antibody
      see all

    Images

    • ab167155 showing +ve staining in Mouse kidney.
    • ab167155 showing +ve staining in Human normal stomach.
    • ab167155 showing +ve staining in Human thyroid gland papillary carcinoma.
    • ab167155 showing +ve staining in Human ovarian carcinoma.
    • ab167155 showing +ve staining in Human normal brain.
    • All lanes : Anti-GLYR1 antibody [EPR10077(B)] (ab167155) at 1/1000 dilution

      Lane 1 : Jurkat cell lysate
      Lane 2 : HeLa cell lysate
      Lane 3 : K562 cell lysate

      Lysates/proteins at 10 µg per lane.

      Predicted band size: 61 kDa

    • Immunohistochemical analysis of paraffin embedded Human colon tissue labeling GLYR1 with ab167155 at a 1/50 dilution.

    References

    ab167155 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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