GM 6001, MMP inhibitor (ab120845)

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Overview

  • Product name

    GM 6001, MMP inhibitor

  • Description

    Broad spectrum MMP inhibitor

  • Alternative names

    • Galardin
    • ilomastat

  • Biological description

    Broad spectrum potent MMP inhibitor. Ki values are 0.4 (MMP-1), 0.5 (MMP-2), 27 (MMP-3), 0.1 (MMP-8), 0.2 (MMP-9), 13.4 (MMP-14) and 0.36 (MMP-26) nM. IC50 value for MMP-7 is 3.7 nM. Pharmacologically active in vivo.

  • Purity

    > 98%

  • CAS Number

    142880-36-2

  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2R)-N4-Hydroxy-N1-[(1S)-2-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)butanediamide

  • Molecular weight

    388.47

  • Molecular formula

    C20H28N4O4

  • PubChem identifier

    132519

  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.

  • Solubility overview

    Soluble in DMSO to 100 mM

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    ONC(=O)C[C@@H](CC(C)C)C(=O)N[C@@H](Cc2cnc1ccccc12)C(=O)NC

  • Source

    Synthetic

References

This product has been referenced in:

  • Zhang H  et al. Role of matrix metalloproteinases and therapeutic benefits of their inhibition in spinal cord injury. Neurotherapeutics 8:206-20 (2011). Read more (PubMed: 21455784) »
  • Levy DE  et al. Matrix metalloproteinase inhibitors: a structure-activity study. J Med Chem 41:199-223 (1998). Read more (PubMed: 9457244) »
  • Grobelny D  et al. Inhibition of human skin fibroblast collagenase, thermolysin, and Pseudomonas aeruginosa elastase by peptide hydroxamic acids. Biochemistry 31:7152-4 (1992). Read more (PubMed: 1322694) »
See all 3 Publications for this product

Publishing research using ab120845? Please let us know so that we can cite the reference in this datasheet.

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