Overview

  • Product name

    Anti-GM-CSF antibody [BVD2-21C11]
    See all GM-CSF primary antibodies
  • Description

    Rat monoclonal [BVD2-21C11] to GM-CSF
  • Host species

    Rat
  • Tested applications

    Suitable for: ICC/IF, IP, IHC-Fr, WB, Flow Cytmore details
  • Species reactivity

    Reacts with: Human, Cynomolgus monkey, Rhesus monkey
  • Immunogen

    Recombinant full length protein corresponding to Human GM-CSF aa 18-144.
    Sequence:

    APARSPSPSTQPWEHVNAIQEARRLLNLSRDTAAEMNETVEVISEMFDLQ EPTCLQTRLE LYKQGLRGSLTKLKGPLTMMASHYKQHCPPTPETSCAT QIITFESFKENLKDFLLVIPFD CWEPVQE


    Database link: P04141

  • Positive control

    • Lymph node and tonsil

Properties

Applications

Our Abpromise guarantee covers the use of ab193345 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 0.5 - 1 µg/ml.
IP Use at 1-2 µg/mg of lysate.
IHC-Fr Use a concentration of 0.5 - 1 µg/ml.
WB Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 22 kDa (predicted molecular weight: 16 kDa).
Flow Cyt Use 0.5-1µg for 106 cells.

ab18450 - Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

 

Target

  • Function

    Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
  • Sequence similarities

    Belongs to the GM-CSF family.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • Colony stimulating factor 2 (granulocyte-macrophage) antibody
    • Colony Stimulating Factor 2 antibody
    • Colony stimulating factor antibody
    • Colony-stimulating factor antibody
    • CSF 2 antibody
    • CSF antibody
    • CSF2 antibody
    • CSF2_HUMAN antibody
    • GM-CSF antibody
    • GMCSF antibody
    • Granulocyte Macrophage Colony Stimulating Factor antibody
    • Granulocyte-macrophage colony-stimulating factor antibody
    • MGC131935 antibody
    • MGC138897 antibody
    • MGI1GM antibody
    • Molgramostin antibody
    • Pluripoietin-a antibody
    • Sargramostim antibody
    see all

References

This product has been referenced in:

  • Pothoven KL  et al. Neutrophils are a major source of the epithelial barrier disrupting cytokine oncostatin M in patients with mucosal airways disease. J Allergy Clin Immunol 139:1966-1978.e9 (2017). IHC-P ; Human . Read more (PubMed: 27993536) »
  • Rasouli J  et al. Expression of GM-CSF in T Cells Is Increased in Multiple Sclerosis and Suppressed by IFN-ß Therapy. J Immunol 194:5085-93 (2015). IHC-Fr ; Human . Read more (PubMed: 25917097) »
See all 2 Publications for this product

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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