Recombinant
RabMAb

Anti-GM130 antibody [EP892Y] - cis-Golgi Marker (ab52649)

Rabbit recombinant monoclonal GM130 antibody [EP892Y]. Validated in WB, IP, IHC, Flow Cyt, ICC/IF and tested in Cow, Dog, Human, Monkey, African green monkey. Cited in 86 publication(s).

Publishing research using ab52649? Please let us know so that we can cite the reference in this datasheet.

ab52649 has been referenced in 88 publications.

  • Wen SW  et al. Breast Cancer-Derived Exosomes Reflect the Cell-of-Origin Phenotype. Proteomics N/A:e1800180 (2019). PubMed: 30672117
  • Tie HC  et al. The spatial separation of processing and transport functions to the interior and periphery of the Golgi stack. Elife 7:N/A (2018). PubMed: 30499774
  • Lee CC  et al. Alpha-tubulin acetyltransferase/MEC-17 regulates cancer cell migration and invasion through epithelial-mesenchymal transition suppression and cell polarity disruption. Sci Rep 8:17477 (2018). PubMed: 30504808
  • Yao Z  et al. Label-free Proteomic Analysis of Exosomes Secreted from THP-1-derived Macrophages Treated with IFN-a Identifies Antiviral Proteins Enriched in Exosomes. J Proteome Res N/A:N/A (2018). PubMed: 30550287
  • Casey CA  et al. Giantin Is Required for Post-Alcohol Recovery of Golgi in Liver Cells. Biomolecules 8:N/A (2018). PubMed: 30453527
  • Farquhar N  et al. Patterns of BAP1 protein expression provide insights into prognostic significance and the biology of uveal melanoma. J Pathol Clin Res 4:26-38 (2018). IHC-P ; Human . PubMed: 29416875
  • Festa BP  et al. Impaired autophagy bridges lysosomal storage disease and epithelial dysfunction in the kidney. Nat Commun 9:161 (2018). PubMed: 29323117
  • Hirst J  et al. Role of the AP-5 adaptor protein complex in late endosome-to-Golgi retrieval. PLoS Biol 16:e2004411 (2018). PubMed: 29381698
  • Lindert U  et al. Insight into the Pathology of a COL1A1 Signal Peptide Heterozygous Mutation Leading to Severe Osteogenesis Imperfecta. Calcif Tissue Int 102:373-379 (2018). IF . PubMed: 29101475
  • Milenkovic A  et al. BEST1 protein stability and degradation pathways differ between autosomal dominant Best disease and autosomal recessive bestrophinopathy accounting for the distinct retinal phenotypes. Hum Mol Genet 27:1630-1641 (2018). PubMed: 29668979
  • Morgan MM  et al. Mammary fibroblasts reduce apoptosis and speed estrogen-induced hyperplasia in an organotypic MCF7-derived duct model. Sci Rep 8:7139 (2018). PubMed: 29740030
  • Wang S  et al. The Absence of DHHC3 Affects Primary and Latent Herpes Simplex Virus 1 Infection. J Virol 92:N/A (2018). PubMed: 29187538
  • Matsunaga K  et al. IL-1ß directly inhibits milk lipid production in lactating mammary epithelial cells concurrently with enlargement of cytoplasmic lipid droplets. Exp Cell Res 370:365-372 (2018). PubMed: 29966663
  • Patwardhan A  et al. Routing of the RAB6 secretory pathway towards the lysosome related organelle of melanocytes. Nat Commun 8:15835 (2017). WB . PubMed: 28607494
  • Pallocca G  et al. Impairment of human neural crest cell migration by prolonged exposure to interferon-beta. Arch Toxicol 91:3385-3402 (2017). ICC/IF . PubMed: 28365849
  • Han F  et al. Globozoospermia and lack of acrosome formation in GM130-deficient mice. Cell Death Dis 8:e2532 (2017). PubMed: 28055014
  • Nadeem L  et al. Progesterone Via its Type-A Receptor Promotes Myometrial Gap Junction Coupling. Sci Rep 7:13357 (2017). Human . PubMed: 29042599
  • Marziali F  et al. Interference of HTLV-1 Tax Protein with Cell Polarity Regulators: Defining the Subcellular Localization of the Tax-DLG1 Interaction. Viruses 9:N/A (2017). ICC/IF . PubMed: 29168728
  • Ye Y  et al. Exosomal miR-141-3p regulates osteoblast activity to promote the osteoblastic metastasis of prostate cancer. Oncotarget 8:94834-94849 (2017). PubMed: 29212270
  • Li RS  et al. Chiral nanoprobes for targeting and long-term imaging of the Golgi apparatus. Chem Sci 8:6829-6835 (2017). PubMed: 29147508
  • Liu X  et al. The BEACH-containing protein WDR81 coordinates p62 and LC3C to promote aggrephagy. J Cell Biol 216:1301-1320 (2017). PubMed: 28404643
  • Abdouh M  et al. Exosomes isolated from cancer patients' sera transfer malignant traits and confer the same phenotype of primary tumors to oncosuppressor-mutated cells. J Exp Clin Cancer Res 36:113 (2017). PubMed: 28854931
  • Ohoka N  et al. SNIPER(TACC3) induces cytoplasmic vacuolization and sensitizes cancer cells to Bortezomib. Cancer Sci 108:1032-1041 (2017). PubMed: 28192613
  • Takacs CN  et al. Green fluorescent protein-tagged apolipoprotein E: A useful marker for the study of hepatic lipoprotein egress. Traffic 18:192-204 (2017). PubMed: 28035714
  • Aksnes H  et al. Molecular determinants of the N-terminal acetyltransferase Naa60 anchoring to the Golgi membrane. J Biol Chem 292:6821-6837 (2017). PubMed: 28196861
  • Jia X  et al. Label-free Proteomic Analysis of Exosomes Derived from Inducible Hepatitis B Virus-Replicating HepAD38 Cell Line. Mol Cell Proteomics 16:S144-S160 (2017). PubMed: 28242843
  • Yang C  et al. EB1 and EB3 regulate microtubule minus end organization and Golgi morphology. J Cell Biol 216:3179-3198 (2017). PubMed: 28814570
  • Fan J  et al. cTAGE5 deletion in pancreatic ß cells impairs proinsulin trafficking and insulin biogenesis in mice. J Cell Biol 216:4153-4164 (2017). PubMed: 29133483
  • Lievens PM  et al. ZDHHC3 Tyrosine Phosphorylation Regulates Neural Cell Adhesion Molecule Palmitoylation. Mol Cell Biol 36:2208-25 (2016). WB ; Mouse . PubMed: 27247265
  • Sin AT & Harrison RE Growth of the Mammalian Golgi Apparatus during Interphase. Mol Cell Biol 36:2344-59 (2016). ICC/IF ; Human . PubMed: 27325676
  • Kilisch M  et al. A dual phosphorylation switch controls 14-3-3-dependent cell surface expression of TASK-1. J Cell Sci 129:831-42 (2016). IF . PubMed: 26743085
  • Espigat-Georger A  et al. Nuclear alignment in myotubes requires centrosome proteins recruited by nesprin-1. J Cell Sci 129:4227-4237 (2016). PubMed: 27802164
  • Uribe ML  et al. Expression pattern in retinal photoreceptors of POMGnT1, a protein involved in muscle-eye-brain disease. Mol Vis 22:658-73 (2016). ICC . PubMed: 27375352
  • Fourriere L  et al. Microtubule-independent secretion requires functional maturation of Golgi elements. J Cell Sci 129:3238-50 (2016). PubMed: 27411366
  • Wilhelmi I  et al. Sec16 alternative splicing dynamically controls COPII transport efficiency. Nat Commun 7:12347 (2016). PubMed: 27492621
  • Cabagnols X  et al. Presence of atypical thrombopoietin receptor (MPL) mutations in triple-negative essential thrombocythemia patients. Blood 127:333-42 (2016). PubMed: 26450985
  • Ahi YS  et al. Functional Interplay Between Murine Leukemia Virus Glycogag, Serinc5, and Surface Glycoprotein Governs Virus Entry, with Opposite Effects on Gammaretroviral and Ebolavirus Glycoproteins. MBio 7:N/A (2016). ICC/IF ; Mouse . PubMed: 27879338
  • Raza S  et al. A bovine herpesvirus 1 pUL51 deletion mutant shows impaired viral growth in vitro and reduced virulence in rabbits. Oncotarget N/A:N/A (2016). PubMed: 26934330
  • Mazzulli JR  et al. a-Synuclein-induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models. Proc Natl Acad Sci U S A 113:1931-6 (2016). PubMed: 26839413
  • Hernández-Tiedra S  et al. Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization. Autophagy 12:2213-2229 (2016). PubMed: 27635674
  • Ma R  et al. Involvement of Rab6a in organelle rearrangement and cytoskeletal organization during mouse oocyte maturation. Sci Rep 6:23560 (2016). PubMed: 27030207
  • Clement CC  et al. The Dendritic Cell Major Histocompatibility Complex II (MHC II) Peptidome Derives from a Variety of Processing Pathways and Includes Peptides with a Broad Spectrum of HLA-DM Sensitivity. J Biol Chem 291:5576-95 (2016). PubMed: 26740625
  • Liang T  et al. The LPV Motif Is Essential for the Efficient Export of Secretory DMP1 From the Endoplasmic Reticulum. J Cell Physiol 231:1468-75 (2016). PubMed: 26595451
  • Elkin SR  et al. Ikarugamycin: A Natural Product Inhibitor of Clathrin-Mediated Endocytosis. Traffic 17:1139-49 (2016). PubMed: 27392092
  • Gan Z  et al. Vimentin Intermediate Filaments Template Microtubule Networks to Enhance Persistence in Cell Polarity and Directed Migration. Cell Syst 3:252-263.e8 (2016). PubMed: 27667364
  • McGourty CA  et al. Regulation of the CUL3 Ubiquitin Ligase by a Calcium-Dependent Co-adaptor. Cell 167:525-538.e14 (2016). PubMed: 27716508
  • Casey CA  et al. Study of Ethanol-Induced Golgi Disorganization Reveals the Potential Mechanism of Alcohol-Impaired N-Glycosylation. Alcohol Clin Exp Res 40:2573-2590 (2016). PubMed: 27748959
  • Wen SW  et al. The Biodistribution and Immune Suppressive Effects of Breast Cancer-Derived Exosomes. Cancer Res 76:6816-6827 (2016). PubMed: 27760789
  • Rodriguez-Teja M  et al. AGE-modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival. J Pathol 235:581-92 (2015). PubMed: 25408555
  • McGowan SE & McCoy DM Fibroblast growth factor signaling in myofibroblasts differs from lipofibroblasts during alveolar septation in mice. Am J Physiol Lung Cell Mol Physiol 309:L463-74 (2015). PubMed: 26138642
  • Wooding FB & Sargeant TJ Immunocytochemical Evidence for Golgi Vesicle Involvement in Milk Fat Globule Secretion. J Histochem Cytochem 63:943-51 (2015). PubMed: 26374828
  • Chukkapalli V  et al. Daclatasvir inhibits hepatitis C virus NS5A motility and hyper-accumulation of phosphoinositides. Virology 476:168-79 (2015). PubMed: 25546252
  • McCormack RM  et al. Perforin-2 is essential for intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria. Elife 4:N/A (2015). WB . PubMed: 26402460
  • Xu D  et al. PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus. Nat Commun 6:8100 (2015). WB . PubMed: 26311497
  • Staudacher JJ  et al. Hypoxia-induced gene expression results from selective mRNA partitioning to the endoplasmic reticulum. Nucleic Acids Res 43:3219-36 (2015). IF . PubMed: 25753659
  • Lindert U  et al. Molecular Consequences of the SERPINH1/HSP47 Mutation in the Dachshund Natural Model of Osteogenesis Imperfecta. J Biol Chem 290:17679-89 (2015). ICC/IF ; Dog . PubMed: 26004778
  • Niso-Santano M  et al. Unsaturated fatty acids induce non-canonical autophagy. EMBO J 34:1025-41 (2015). WB ; Human . PubMed: 25586377
  • Klünder S  et al. Site-1 protease-activated formation of lysosomal targeting motifs is independent of the lipogenic transcription control. J Lipid Res 56:1625-32 (2015). Mouse . PubMed: 26108224
  • Sin YY  et al. Small heat shock protein 20 (Hsp20) facilitates nuclear import of protein kinase D 1 (PKD1) during cardiac hypertrophy. Cell Commun Signal 13:16 (2015). PubMed: 25889640
  • Popa A  et al. Direct binding of retromer to human papillomavirus type 16 minor capsid protein L2 mediates endosome exit during viral infection. PLoS Pathog 11:e1004699 (2015). PubMed: 25693203
  • Mitsuda S  et al. Ursolic acid, a natural pentacyclic triterpenoid, inhibits intracellular trafficking of proteins and induces accumulation of intercellular adhesion molecule-1 linked to high-mannose-type glycans in the endoplasmic reticulum. FEBS Open Bio 4:229-39 (2014). ICC/IF ; Human . PubMed: 24649404
  • Hofmann K  et al. A novel alkyne cholesterol to trace cellular cholesterol metabolism and localization. J Lipid Res 55:583-91 (2014). PubMed: 24334219
  • Henry SC  et al. Palmitoylation of the Immunity Related GTPase, Irgm1: Impact on Membrane Localization and Ability to Promote Mitochondrial Fission. PLoS One 9:e95021 (2014). IF ; Mouse . PubMed: 24751652
  • DeVorkin L  et al. The Drosophila effector caspase Dcp-1 regulates mitochondrial dynamics and autophagic flux via SesB. J Cell Biol 205:477-492 (2014). PubMed: 24862573
  • Maier PJ  et al. Ischemia-like oxygen and glucose deprivation mediates down-regulation of cell surface ?-aminobutyric acidB receptors via the endoplasmic reticulum (ER) stress-induced transcription factor CCAAT/enhancer-binding protein (C/EBP)-homologous protein (CHOP). J Biol Chem 289:12896-907 (2014). PubMed: 24668805
  • Wiernasz E  et al. Ttyh1 protein is expressed in glia in vitro and shows elevated expression in activated astrocytes following status epilepticus. Neurochem Res 39:2516-26 (2014). WB, ICC, IHC ; Rat . PubMed: 25316497
  • McDonald AG  et al. Galactosyltransferase 4 is a major control point for glycan branching in N-linked glycosylation. J Cell Sci 127:5014-26 (2014). ICC/IF ; Chinese hamster . PubMed: 25271059
  • Wong M & Munro S Membrane trafficking. The specificity of vesicle traffic to the Golgi is encoded in the golgin coiled-coil proteins. Science 346:1256898 (2014). PubMed: 25359980
  • Caviness K  et al. Complex expression of the UL136 gene of human cytomegalovirus results in multiple protein isoforms with unique roles in replication. J Virol 88:14412-25 (2014). WB . PubMed: 25297993
  • Crambert G  et al. Epithelial sodium channel abundance is decreased by an unfolded protein response induced by hyperosmolality. Physiol Rep 2:N/A (2014). WB, ICC/IF ; Mouse . PubMed: 25413317
  • Petrosyan A  et al. Restoration of compact Golgi morphology in advanced prostate cancer enhances susceptibility to galectin-1-induced apoptosis by modifying mucin O-glycan synthesis. Mol Cancer Res 12:1704-16 (2014). PubMed: 25086069
  • Park AK  et al. Targeted disruption of Tbc1d20 with zinc-finger nucleases causes cataracts and testicular abnormalities in mice. BMC Genet 15:135 (2014). PubMed: 25476608
  • Philippe M  et al. Discs large 1 (Dlg1) scaffolding protein participates with clathrin and adaptator protein complex 1 (AP-1) in forming Weibel-Palade bodies of endothelial cells. J Biol Chem 288:13046-56 (2013). PubMed: 23532850
  • Haataja L  et al. Proinsulin intermolecular interactions during secretory trafficking in pancreatic ß cells. J Biol Chem 288:1896-906 (2013). IHC-P ; Mouse . PubMed: 23223446
  • Maier B  et al. The novel actin/focal adhesion-associated protein MISP is involved in mitotic spindle positioning in human cells. Cell Cycle 12:1457-71 (2013). PubMed: 23574715
  • Nunes P  et al. Hypertonic stress promotes autophagy and microtubule-dependent autophagosomal clusters. Autophagy 9:550-67 (2013). PubMed: 23380587
  • Rogers RS  et al. Proteomics analyses of human optic nerve head astrocytes following biomechanical strain. Mol Cell Proteomics 11:M111.012302 (2012). WB ; Human . PubMed: 22126795
  • Valentine CD & Haggie PM Confinement of ß(1)- and ß(2)-adrenergic receptors in the plasma membrane of cardiomyocyte-like H9c2 cells is mediated by selective interactions with PDZ domain and A-kinase anchoring proteins but not caveolae. Mol Biol Cell 22:2970-82 (2011). WB . PubMed: 21680711
  • Izu Y  et al. Type XII collagen regulates osteoblast polarity and communication during bone formation. J Cell Biol 193:1115-30 (2011). IHC . PubMed: 21670218
  • Schönherr C  et al. The Neuroblastoma ALK(I1250T) Mutation Is a Kinase-Dead RTK In Vitro and In Vivo. Transl Oncol 4:258-65 (2011). ICC/IF . PubMed: 21804922
  • Milenkovic VM  et al. Disease-associated missense mutations in bestrophin-1 affect cellular trafficking and anion conductance. J Cell Sci 124:2988-96 (2011). ICC/IF ; Dog . PubMed: 21878505
  • Gorleku OA  et al. Endoplasmic Reticulum Localization of DHHC Palmitoyltransferases Mediated by Lysine-based Sorting Signals. J Biol Chem 286:39573-84 (2011). ICC/IF . PubMed: 21926431
  • Lan X  et al. HIV-1 reduces Abeta-degrading enzymatic activities in primary human mononuclear phagocytes. J Immunol 186:6925-32 (2011). IF . PubMed: 21551363
  • Maïga O  et al. Identification of mitogen-activated protein/extracellular signal-responsive kinase kinase 2 as a novel partner of the scaffolding protein human homolog of disc-large. FEBS J 278:2655-65 (2011). PubMed: 21615688
  • Ramabhadran V  et al. Splice variant-specific cellular function of the formin INF2 in maintenance of Golgi architecture. Mol Biol Cell 22:4822-33 (2011). PubMed: 21998196
  • Ma W  et al. Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease. J Clin Invest 121:4548-66 (2011). PubMed: 22005303
  • van der Velden LM  et al. Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases. J Biol Chem 285:40088-96 (2010). ICC/IF ; Human . PubMed: 20947505
  • Schaheen B  et al. Derlin-dependent accumulation of integral membrane proteins at cell surfaces. J Cell Sci 122:2228-39 (2009). PubMed: 19509052

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