Anti-GM2A antibody (ab113416)
Key features and details
- Goat polyclonal to GM2A
- Suitable for: WB
- Reacts with: Rat
- Isotype: IgG
Overview
-
Product name
Anti-GM2A antibody
See all GM2A primary antibodies -
Description
Goat polyclonal to GM2A -
Host species
Goat -
Tested Applications & Species
See all applications and species dataApplication Species WB Rat
-
Immunogen
Synthetic peptide corresponding to Human GM2A aa 150-250 (internal sequence).
Database link: NP_000396.2 -
Positive control
- WB: Rat Kidney lysate
-
General notes
This product was previously labelled as GM2-AP
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 99% Tris buffered saline, 0.5% BSA -
Concentration information loading... -
Purity
Immunogen affinity purified -
Purification notes
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
-
Positive Controls
-
Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab113416 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Tested applications are guaranteed to work and covered by our Abpromise guarantee.
Predicted to work for this combination of applications and species but not guaranteed.
Does not work for this combination of applications and species.
| Application | Species |
|---|---|
| WB |
Rat
|
| All applications |
Mouse
|
| Application | Abreviews | Notes |
|---|---|---|
| WB |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 21 kDa.
A 1 hour primary incubation is recommended for this product. |
| Notes |
|---|
|
WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 21 kDa. A 1 hour primary incubation is recommended for this product. |
Target
-
Function
Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. -
Involvement in disease
Defects in GM2A are the cause of GM2-gangliosidosis type AB (GM2GAB) [MIM:272750]; also known as Tay-Sachs disease AB variant. GM2-gangliosidosis is an autosomal recessive lysosomal storage disease marked by the accumulation of GM2 gangliosides in the neuronal cells. GM2GAB is characterized by GM2 gangliosides accumulation in the presence of both hexosaminidase A and B. -
Post-translational
modificationsThe serines in positions 32 and 33 are absent in 80% of the sequenced protein. -
Cellular localization
Lysosome. - Information by UniProt
-
Database links
- Entrez Gene: 14667 Mouse
- Entrez Gene: 282838 Rat
- SwissProt: Q60648 Mouse
- Unigene: 287807 Mouse
- Unigene: 98783 Rat
-
Alternative names
- Cerebroside sulfate activator protein antibody
- ganglioside GM2 activator antibody
- Ganglioside GM2 activator isoform short antibody
see all
Images
-
Western blot - Anti-GM2A antibody (ab113416)ab113416 at 0.3 µg/ml + Rat kidney lysate at 35 µg
Predicted band size: 21 kDa
Datasheets and documents
References (0)
ab113416 has not yet been referenced specifically in any publications.
