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    gm2a-antibody-ab113416.pdf

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Tags & Cell Markers Subcellular Markers Organelles Lysosome
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Anti-GM2A antibody (ab113416)

  • Datasheet
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Western blot - Anti-GM2A antibody (ab113416)

    Key features and details

    • Goat polyclonal to GM2A
    • Suitable for: WB
    • Reacts with: Rat
    • Isotype: IgG

    You may also be interested in

    Secondary
    Product image
    Donkey Anti-Goat IgG H&L (HRP) (ab97110)

    View more associated products

    Overview

    • Product name

      Anti-GM2A antibody
      See all GM2A primary antibodies
    • Description

      Goat polyclonal to GM2A
    • Host species

      Goat
    • Tested Applications & Species

      Application Species
      WB
      Rat
      See all applications and species data
    • Immunogen

      Synthetic peptide corresponding to Human GM2A aa 150-250 (internal sequence).
      Database link: NP_000396.2

      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
    • Positive control

      • WB: Rat Kidney lysate
    • General notes

       This product was previously labelled as GM2-AP

       

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
    • Storage buffer

      pH: 7.30
      Preservative: 0.02% Sodium azide
      Constituents: 99% Tris buffered saline, 0.5% BSA
    • Concentration information loading...
    • Purity

      Immunogen affinity purified
    • Purification notes

      Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Tags & Cell Markers
      • Subcellular Markers
      • Organelles
      • Lysosome
      • Signal Transduction
      • Metabolism
      • Lipid metabolism
      • Metabolism
      • Types of disease
      • Cancer

    Associated products

    • Compatible Secondaries

      • Donkey Anti-Goat IgG H&L (Alexa Fluor® 488) (ab150129)
      • Donkey Anti-Goat IgG H&L (HRP) (ab205723)
    • Isotype control

      • Goat IgG, polyclonal - Isotype Control (ab37373)
    • Positive Controls

      • HEK-293 whole cell lysate (ab7902)
    • Recombinant Protein

      • Recombinant Human GM2A protein (BSA and azide free) (ab178464)

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab113416 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Guaranteed

    Tested applications are guaranteed to work and covered by our Abpromise guarantee.

    Predicted

    Predicted to work for this combination of applications and species but not guaranteed.

    Incompatible

    Does not work for this combination of applications and species.

    Application Species
    WB
    Rat
    All applications
    Mouse
    Application Abreviews Notes
    WB
    Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 21 kDa.

    A 1 hour primary incubation is recommended for this product.

    Notes
    WB
    Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 21 kDa.

    A 1 hour primary incubation is recommended for this product.

    Target

    • Function

      Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.
    • Involvement in disease

      Defects in GM2A are the cause of GM2-gangliosidosis type AB (GM2GAB) [MIM:272750]; also known as Tay-Sachs disease AB variant. GM2-gangliosidosis is an autosomal recessive lysosomal storage disease marked by the accumulation of GM2 gangliosides in the neuronal cells. GM2GAB is characterized by GM2 gangliosides accumulation in the presence of both hexosaminidase A and B.
    • Post-translational
      modifications

      The serines in positions 32 and 33 are absent in 80% of the sequenced protein.
    • Cellular localization

      Lysosome.
    • Target information above from: UniProt accession P17900 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 14667 Mouse
      • Entrez Gene: 282838 Rat
      • SwissProt: Q60648 Mouse
      • Unigene: 287807 Mouse
      • Unigene: 98783 Rat
      • Alternative names

        • Cerebroside sulfate activator protein antibody
        • ganglioside GM2 activator antibody
        • Ganglioside GM2 activator isoform short antibody
        • Ganglioside GM2 activator precursor antibody
        • GM2 activator antibody
        • GM2 AP antibody
        • GM2 ganglioside activator antibody
        • GM2 ganglioside activator protein antibody
        • GM2-AP antibody
        • GM2A antibody
        • GM2AP antibody
        • OTTHUMP00000160619 antibody
        • SAP 3 antibody
        • SAP-3 antibody
        • SAP3 antibody
        • SAP3_HUMAN antibody
        • Shingolipid activator protein 3 antibody
        • Sphingolipid activator protein 3 antibody
        see all

      Images

      • Western blot - Anti-GM2A antibody (ab113416)
        Western blot - Anti-GM2A antibody (ab113416)
        ab113416 at 0.3 µg/ml + Rat kidney lysate at 35 µg

        Predicted band size: 21 kDa

      Protocols

      • Western blot protocols

      Click here to view the general protocols

      Datasheets and documents

      • Datasheet
    • References (0)

      Publishing research using ab113416? Please let us know so that we can cite the reference in this datasheet.

      ab113416 has not yet been referenced specifically in any publications.

      Customer reviews and Q&As

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