Anti-GM2A antibody (ab118433)
- Datasheet
- References
- Protocols
Overview
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Product name
Anti-GM2A antibody
See all GM2A primary antibodies -
Description
Rabbit polyclonal to GM2A -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide corresponding to Human GM2A (N terminal) conjugated to keyhole limpet haemocyanin.
Database link: NP_000396.2 -
Positive control
- Human kidney and skin tissues.
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General notes
This product was previously labelled as GM2-AP
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
Preservative: 0.1% Sodium azide
Constituent: 99% PBS -
Concentration information loading... -
Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
Our Abpromise guarantee covers the use of ab118433 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IHC-P | Use a concentration of 10 - 12.5 µg/ml. |
Target
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Function
Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. -
Involvement in disease
Defects in GM2A are the cause of GM2-gangliosidosis type AB (GM2GAB) [MIM:272750]; also known as Tay-Sachs disease AB variant. GM2-gangliosidosis is an autosomal recessive lysosomal storage disease marked by the accumulation of GM2 gangliosides in the neuronal cells. GM2GAB is characterized by GM2 gangliosides accumulation in the presence of both hexosaminidase A and B. -
Post-translational
modificationsThe serines in positions 32 and 33 are absent in 80% of the sequenced protein. -
Cellular localization
Lysosome. - Information by UniProt
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Database links
- Entrez Gene: 2760 Human
- Omim: 613109 Human
- SwissProt: P17900 Human
- Unigene: 483873 Human
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Alternative names
- Cerebroside sulfate activator protein antibody
- ganglioside GM2 activator antibody
- Ganglioside GM2 activator isoform short antibody
see all
Images
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GM2A antibody (ab118433)ab118433 at 12.5µg/ml staining GM2A in Formalin-fixed, Paraffin-embedded Human kidney tissue by Immunohistochemistry.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GM2A antibody (ab118433)ab118433 at 12.5µg/ml staining GM2A in Formalin-fixed, Paraffin-embedded Human skin tissue by Immunohistochemistry.
Protocols
References
ab118433 has not yet been referenced specifically in any publications.
