Key features and details
- Rabbit polyclonal to GM2A
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-GM2A antibody
See all GM2A primary antibodies
DescriptionRabbit polyclonal to GM2A
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Synthetic peptide corresponding to Human GM2A (N terminal) conjugated to keyhole limpet haemocyanin.
Database link: NP_000396.2
- Human Kidney and Skin tissues.
This product was previously labelled as GM2-AP
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Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferPreservative: 0.1% Sodium azide
Constituent: 99% PBS
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab118453 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use a concentration of 5 - 7.5 µg/ml.|
FunctionBinds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.
Involvement in diseaseDefects in GM2A are the cause of GM2-gangliosidosis type AB (GM2GAB) [MIM:272750]; also known as Tay-Sachs disease AB variant. GM2-gangliosidosis is an autosomal recessive lysosomal storage disease marked by the accumulation of GM2 gangliosides in the neuronal cells. GM2GAB is characterized by GM2 gangliosides accumulation in the presence of both hexosaminidase A and B.
modificationsThe serines in positions 32 and 33 are absent in 80% of the sequenced protein.
- Information by UniProt
- Cerebroside sulfate activator protein antibody
- ganglioside GM2 activator antibody
- Ganglioside GM2 activator isoform short antibody
ab118453 has not yet been referenced specifically in any publications.