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    gm2a-antibody-ab150476.pdf

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Anti-GM2A antibody (ab150476)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GM2A antibody (ab150476)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GM2A antibody (ab150476)

Key features and details

  • Rabbit polyclonal to GM2A
  • Suitable for: IHC-P
  • Reacts with: Human
  • Isotype: IgG

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Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

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Overview

  • Product name

    Anti-GM2A antibody
    See all GM2A primary antibodies
  • Description

    Rabbit polyclonal to GM2A
  • Host species

    Rabbit
  • Specificity

    BLAST analysis of the peptide immunogen showed no homology with other Human proteins.
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Chimpanzee, Monkey, Gorilla, Common marmoset, Orangutan
  • Immunogen

    Synthetic peptide corresponding to Human GM2A (internal sequence).
    Database link: NP_000396.2

  • Positive control

    • Human kidney and Human breast tissues
  • General notes

     This product was previously labelled as GM2-AP

     

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C.
  • Storage buffer

    Preservative: 0.1% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Tags & Cell Markers
    • Subcellular Markers
    • Organelles
    • Lysosome
    • Signal Transduction
    • Metabolism
    • Lipid metabolism

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
  • Recombinant Protein

    • Recombinant Human GM2A protein (BSA and azide free) (ab178464)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab150476 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
Notes
IHC-P
Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function

    Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.
  • Involvement in disease

    Defects in GM2A are the cause of GM2-gangliosidosis type AB (GM2GAB) [MIM:272750]; also known as Tay-Sachs disease AB variant. GM2-gangliosidosis is an autosomal recessive lysosomal storage disease marked by the accumulation of GM2 gangliosides in the neuronal cells. GM2GAB is characterized by GM2 gangliosides accumulation in the presence of both hexosaminidase A and B.
  • Post-translational
    modifications

    The serines in positions 32 and 33 are absent in 80% of the sequenced protein.
  • Cellular localization

    Lysosome.
  • Target information above from: UniProt accession P17900 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 2760 Human
    • Omim: 613109 Human
    • SwissProt: P17900 Human
    • Unigene: 483873 Human
    • Alternative names

      • Cerebroside sulfate activator protein antibody
      • ganglioside GM2 activator antibody
      • Ganglioside GM2 activator isoform short antibody
      • Ganglioside GM2 activator precursor antibody
      • GM2 activator antibody
      • GM2 AP antibody
      • GM2 ganglioside activator antibody
      • GM2 ganglioside activator protein antibody
      • GM2-AP antibody
      • GM2A antibody
      • GM2AP antibody
      • OTTHUMP00000160619 antibody
      • SAP 3 antibody
      • SAP-3 antibody
      • SAP3 antibody
      • SAP3_HUMAN antibody
      • Shingolipid activator protein 3 antibody
      • Sphingolipid activator protein 3 antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GM2A antibody (ab150476)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GM2A antibody (ab150476)

      Immunohistochemical analysis of paraffin embedded Human kidney tissue labelling GM2A with ab150476 antibody at a concentration of 5 µg/ml.

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GM2A antibody (ab150476)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GM2A antibody (ab150476)

      Immunohistochemical analysis of paraffin embedded Human breast tissue labelling GM2A with ab150476 antibody at a concentration of 5 µg/ml.

    Protocols

    • Immunohistochemistry protocols

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (0)

    Publishing research using ab150476? Please let us know so that we can cite the reference in this datasheet.

    ab150476 has not yet been referenced specifically in any publications.

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