Anti-GM2A antibody (ab150476)
Key features and details
- Rabbit polyclonal to GM2A
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-GM2A antibody
See all GM2A primary antibodies -
Description
Rabbit polyclonal to GM2A -
Host species
Rabbit -
Specificity
BLAST analysis of the peptide immunogen showed no homology with other Human proteins. -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Chimpanzee, Monkey, Gorilla, Common marmoset, Orangutan
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Immunogen
Synthetic peptide corresponding to Human GM2A (internal sequence).
Database link: NP_000396.2 -
Positive control
- Human kidney and Human breast tissues
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General notes
This product was previously labelled as GM2-AP
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. -
Storage buffer
Preservative: 0.1% Sodium azide
Constituent: 99% PBS -
Concentration information loading... -
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab150476 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IHC-P |
Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
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| Notes |
|---|
|
IHC-P
Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. |
Target
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Function
Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. -
Involvement in disease
Defects in GM2A are the cause of GM2-gangliosidosis type AB (GM2GAB) [MIM:272750]; also known as Tay-Sachs disease AB variant. GM2-gangliosidosis is an autosomal recessive lysosomal storage disease marked by the accumulation of GM2 gangliosides in the neuronal cells. GM2GAB is characterized by GM2 gangliosides accumulation in the presence of both hexosaminidase A and B. -
Post-translational
modificationsThe serines in positions 32 and 33 are absent in 80% of the sequenced protein. -
Cellular localization
Lysosome. - Information by UniProt
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Database links
- Entrez Gene: 2760 Human
- Omim: 613109 Human
- SwissProt: P17900 Human
- Unigene: 483873 Human
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Alternative names
- Cerebroside sulfate activator protein antibody
- ganglioside GM2 activator antibody
- Ganglioside GM2 activator isoform short antibody
see all
Images
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GM2A antibody (ab150476)
Immunohistochemical analysis of paraffin embedded Human kidney tissue labelling GM2A with ab150476 antibody at a concentration of 5 µg/ml.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GM2A antibody (ab150476)Immunohistochemical analysis of paraffin embedded Human breast tissue labelling GM2A with ab150476 antibody at a concentration of 5 µg/ml.
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab150476 has not yet been referenced specifically in any publications.