Overview

  • Product name

  • Description

    Rabbit polyclonal to GM2A
  • Host species

    Rabbit
  • Specificity

    BLAST analysis of the peptide immunogen showed no homology with other Human proteins.
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Chimpanzee, Monkey, Gorilla, Common marmoset, Orangutan
  • Immunogen

    Synthetic peptide corresponding to Human GM2A (internal sequence).
    Database link: NP_000396.2

  • Positive control

    • Human kidney and Human breast tissues
  • General notes

     This product was previously labelled as GM2-AP

     

Properties

Applications

Our Abpromise guarantee covers the use of ab150476 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function

    Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.
  • Involvement in disease

    Defects in GM2A are the cause of GM2-gangliosidosis type AB (GM2GAB) [MIM:272750]; also known as Tay-Sachs disease AB variant. GM2-gangliosidosis is an autosomal recessive lysosomal storage disease marked by the accumulation of GM2 gangliosides in the neuronal cells. GM2GAB is characterized by GM2 gangliosides accumulation in the presence of both hexosaminidase A and B.
  • Post-translational
    modifications

    The serines in positions 32 and 33 are absent in 80% of the sequenced protein.
  • Cellular localization

    Lysosome.
  • Information by UniProt
  • Database links

  • Alternative names

    • Cerebroside sulfate activator protein antibody
    • ganglioside GM2 activator antibody
    • Ganglioside GM2 activator isoform short antibody
    • Ganglioside GM2 activator precursor antibody
    • GM2 activator antibody
    • GM2 AP antibody
    • GM2 ganglioside activator antibody
    • GM2 ganglioside activator protein antibody
    • GM2-AP antibody
    • GM2A antibody
    • GM2AP antibody
    • OTTHUMP00000160619 antibody
    • SAP 3 antibody
    • SAP-3 antibody
    • SAP3 antibody
    • SAP3_HUMAN antibody
    • Shingolipid activator protein 3 antibody
    • Sphingolipid activator protein 3 antibody
    see all

Images

  • Immunohistochemical analysis of paraffin embedded Human kidney tissue labelling GM2A with ab150476 antibody at a concentration of 5 µg/ml.

  • Immunohistochemical analysis of paraffin embedded Human breast tissue labelling GM2A with ab150476 antibody at a concentration of 5 µg/ml.

References

ab150476 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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