GMQ hydrochloride, ASIC3 channel activator (ab146005)

Overview

  • Product name

    GMQ hydrochloride, ASIC3 channel activator
  • Description

    Selective ASIC3 channel activator. Competitive GABAA receptor antagonist.
  • Biological description

    Selective ASIC3 channel activator at pH 7.4. Alters the pH dependence of ASIC1a and ASIC1b; does not affect the activation curve of ASIC2a. Competitive GABAA receptor antagonist (IC50 = 390 nM). Shows nociceptive effects in vivo.
  • Purity

    > 98%
  • CAS Number

    5361-15-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-(4-Methyl-2-quinazolinyl)guanidine hydrochloride
  • Molecular weight

    237.69
  • Molecular formula

    C10H11N5.HCl
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 50 mM and in water to 5 mM (with warming)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Mercado F  et al. Inhibition of peripheral nociceptors by aminoglycosides produces analgesia in inflammatory pain models in the rat. Inflammation 38:649-57 (2015). Read more (PubMed: 25028102) »
  • Xiao X  et al. 2-Guanidine-4-methylquinazoline acts as a novel competitive antagonist of A type ?-aminobutyric acid receptors. Neuropharmacology 75:126-37 (2013). Read more (PubMed: 23916476) »
  • Li WG  et al. ASIC3 channels integrate agmatine and multiple inflammatory signals through the nonproton ligand sensing domain. Mol Pain 6:88 (2010). Read more (PubMed: 21143836) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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