Description

  • Product name

    GNAI1 + GNAI2 peptide
  • Animal free

    No
  • Nature

    Synthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab5006 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form

    Lyophilised
  • Additional notes


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human G protein alpha inhibitor 1/2, catalog ab3522. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

     This product was previously labelled as G protein alpha inhibitor 1, G Protein alpha Inhibitor 1+2

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

  • Reconstitution
    >95% pure, lyophilized synthetic peptide. Reconstitute with 0.1 ml of distilled water.

General Info

  • Alternative names

    • Adenylate cyclase-inhibiting G alpha protein
    • Gi
    • Gi1 protein alpha subunit
    • Gi2 protein alpha subunit
    • GIP
    • GNAI1
    • GNAI1_HUMAN
    • GNAI2
    • GNAI2B
    • Guanine nucleotide binding protein G(i) alpha 1 subunit
    • Guanine nucleotide binding protein G(i) alpha 2 subunit
    • Guanine nucleotide-binding protein G(i) subunit alpha-1
    see all
  • Function

    Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.
  • Sequence similarities

    Belongs to the G-alpha family. G(i/o/t/z) subfamily.
  • Cellular localization

    Nucleus. Cytoplasm. Cell membrane. Cytoplasm > cytoskeleton > centrosome. Localized at the plasma membrane throughout mitosis. Colocalizes with RIC8A and RGS14 at the plasma membrane (By similarity). Localizes in the centrosomes of interphase and mitotic cells, but not in centrosomes during cytokinesis. Detected at the cleavage furrow or the midbody.
  • Information by UniProt

References

ab5006 has not yet been referenced specifically in any publications.

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