Product nameAnti-GnRH antibody
See all GnRH primary antibodies
DescriptionRabbit polyclonal to GnRH
Tested applicationsSuitable for: ELISA, IHC-Fr, IHC-P, RIAmore details
Species reactivityReacts with: Human
Full length protein (Human) conjugated to BSA.
General notesLHRH is also known as Gonadotropin-releasing hormone (GNRH).
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferLiquid antiserum
Light chain typeunknown
Our Abpromise guarantee covers the use of ab8491 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Advised working dilutions are 1:50-1:100.
Dilution buffer is 0.15 M PBS with 1% Ovalbumin and 0.09% sodium azide.
Optimal dilution should be tested by serial dilution.
RelevanceGonadotropin releasing hormone (GnRH), also known as luteinizing hormone releasing hormone (LHRH), is a key molecule in the regulation of reproduction in vertebrates. GnRH, a decapeptide, is produced by neurons in the medial basal hypothalamus (MBH) and secreted in a pulsatile manner into the cardiovascular system. The frequency and amplitude of GnRH pulses determine secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary. Higher frequencies (greater than one pulse per hour) stimulate LH secretion while lower frequencies stimulate FSH secretion. The generation of GnRH pulses is effected by numerous stimuli, such as neural, hormonal and environmental. Therefore, behavioral and physiological conditions such as sleep, exercise, and stress can affect the GnRH pulses and cause a disruption of the normal cycle. Recent studies show that GnRH also has a role in mediating cancer. GnRH has been shown to inhibit the growth of human uterine leiomyloma cells by suppressing proliferation and inducing apoptosis. GnRH analogs have been used to treat a wide variety of reproductive cancers, although the side effects of using such compounds are often quite severe.
- GnRH associated peptide 1 antibody
- GNRH1 antibody
- Gonadotrophin releasing hormone 1 antibody
ab8491 has not yet been referenced specifically in any publications.