Recombinant Anti-GNS antibody [EPR8329(2)] - BSA and Azide free (ab249077)


  • Product name

    Anti-GNS antibody [EPR8329(2)] - BSA and Azide free
    See all GNS primary antibodies
  • Description

    Rabbit monoclonal [EPR8329(2)] to GNS - BSA and Azide free
  • Host species

  • Tested applications

    Suitable for: IP, WBmore details
    Unsuitable for: Flow Cyt,ICC/IF or IHC-P
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human GNS. The exact sequence is proprietary.
    Database link: P15586

  • General notes

    Ab249077 is the carrier-free version of ab154177. This format is designed for use in antibody labeling, including fluorochromes, metal isotopes, oligonucleotides, enzymes.


    Our carrier-free formats are supplied in a buffer free of BSA, sodium azide and glycerol for higher conjugation efficiency.

    Use our conjugation kits  for antibody conjugates that are ready-to-use in as little as 20 minutes with <1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

    ab249077 is compatible with the Maxpar® Antibody Labeling Kit from Fluidigm.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.



Our Abpromise guarantee covers the use of ab249077 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at an assay dependent concentration.
WB Use at an assay dependent concentration. Predicted molecular weight: 62 kDa.
  • Application notes
    Is unsuitable for Flow Cyt,ICC/IF or IHC-P.
  • Target

    • Involvement in disease

      Defects in GNS are the cause of mucopolysaccharidosis type 3D (MPS3D) [MIM:252940]; also known as Sanfilippo D syndrome. MPS3D is a form of mucopolysaccharidosis type 3, an autosomal recessive lysosomal storage disease due to impaired degradation of heparan sulfate. MPS3 is characterized by severe central nervous system degeneration, but only mild somatic disease. Onset of clinical features usually occurs between 2 and 6 years; severe neurologic degeneration occurs in most patients between 6 and 10 years of age, and death occurs typically during the second or third decade of life.
    • Sequence similarities

      Belongs to the sulfatase family.
    • Post-translational

      The form A (78 kDa) is processed by internal peptidase cleavage to a 32 kDa N-terminal species (form B) and a 48 kDa C-terminal species.
      The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
    • Cellular localization

    • Information by UniProt
    • Database links

    • Alternative names

      • 2610016K11Rik antibody
      • AU042285 antibody
      • C87209 antibody
      • G6S antibody
      • Glucosamine (N-acetyl) 6 sulfatase antibody
      • Glucosamine 6 sulfatase antibody
      • Glucosamine-6-sulfatase antibody
      • GNS antibody
      • GNS_HUMAN antibody
      • MGC21274 antibody
      • N acetylglucosamine 6 sulfatase [Precursor] antibody
      • N-acetylglucosamine-6-sulfatase antibody
      • N28088 antibody
      see all


    ab249077 has not yet been referenced specifically in any publications.

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