Go 6976, PKC inhibitor (ab141413)
Key features and details
- Potent PKC inhibitor. Selective for PKCα and PKCβ
- CAS Number: 136194-77-9
- Purity: > 99%
- Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Go 6976, PKC inhibitor -
Description
Potent PKC inhibitor. Selective for PKCα and PKCβ -
Purity
> 99% -
General notes
This product is manufactured by BioVision, an Abcam company and was previously called 1711 Gö 6976. 1711-500 is the same size as the 500 µg size of ab141413.
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CAS Number
136194-77-9 -
Chemical structure
Properties
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Chemical name
5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile -
Molecular weight
378.43 -
Molecular formula
C24H18N4O -
PubChem identifier
3501 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN1C2=CC=CC=C2C3=C4C(=C5C6=CC=CC=C6N(C5=C31)CCC#N)CNC4=O -
Source
Synthetic
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Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (8)
ab141413 has been referenced in 8 publications.
- Zhang H et al. Signaling pathways involved in NMDA-induced suppression of M-channels in corticotropin-releasing hormone neurons in central amygdala. J Neurochem 161:478-491 (2022). PubMed: 35583089
- Qian A et al. A rapid degradation of calponin 2 is required for cytokinesis. Am J Physiol Cell Physiol 321:C355-C368 (2021). PubMed: 34133238
- Jeong J et al. Inhibition of ezrin causes PKCa-mediated internalization of erbb2/HER2 tyrosine kinase in breast cancer cells. J Biol Chem 294:887-901 (2019). PubMed: 30463939
- Yang WC et al. Therapeutic hypercapnia reduces blood-brain barrier damage possibly via protein kinase Ce in rats with lateral fluid percussion injury. J Neuroinflammation 16:36 (2019). PubMed: 30760300
- Xue X et al. Protein kinase Ca drives fibroblast activation and kidney fibrosis by stimulating autophagic flux. J Biol Chem 293:11119-11130 (2018). PubMed: 29794026
- Ren J et al. Rictor/mammalian target of rapamycin complex 2 promotes macrophage activation and kidney fibrosis. J Pathol 242:488-499 (2017). PubMed: 28585302
- Pacitto R et al. CXCL12-induced macropinocytosis modulates two distinct pathways to activate mTORC1 in macrophages. J Leukoc Biol 101:683-692 (2017). PubMed: 28250113
- Gu Y et al. Epac-protein kinase C alpha signaling in purinergic P2X3R-mediated hyperalgesia after inflammation. Pain 157:1541-50 (2016). PubMed: 26963850