Overview

  • Product name

    Go 6976 (DMSO solution), PKC inhibitor
  • Description

    Potent PKC inhibitor. Selective for PKCα and PKCβ.
  • Biological description

    Potent, selective PKC inhibitor (IC50 values are 2.3 and 6.2 nM at PKCα and β1, respectively). Selectively inhibits Ca2+-dependent PKC isoforms over Ca2+-independent. No inhibitory activity at PKCδ, ε or ζ. Antitumor agent. Active in vitro and in vivo.

    Also available as a solid (ab141413).
  • Purity

    > 98%
  • CAS Number

    136194-77-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile
  • Molecular weight

    378.43
  • Molecular formula

    C24H18N4O
  • PubChem identifier

    3501
  • Storage instructions

    Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
  • Solubility overview

    Supplied in DMSO (10 mM)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN1C2=CC=CC=C2C3=C4C(=C5C6=CC=CC=C6N(C5=C31)CCC#N)CNC4=O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Lee HJ  et al. Noncovalent wild-type-sparing inhibitors of EGFR T790M. Cancer Discov 3:168-81 (2013). Read more (PubMed: 23229345) »
  • Feng Z  et al. Chk1 inhibitor Gö6976 enhances the sensitivity of nasopharyngeal carcinoma cells to radiotherapy and chemotherapy in vitro and in vivo. Cancer Lett 297:190-7 (2010). Read more (PubMed: 20619533) »
  • Martiny-Baron G  et al. Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976. J Biol Chem 268:9194-7 (1993). Read more (PubMed: 8486620) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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