Key features and details
- Potent PKC inhibitor. Selective for PKCα and PKCβ
- CAS Number: 136194-77-9
- Purity: > 99%
- Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
Product nameGo 6976, PKC inhibitor
DescriptionPotent PKC inhibitor. Selective for PKCα and PKCβ
Potent, selective PKC inhibitor (IC50 values are 2.3 and 6.2 nM at PKCα and β1, respectively). Selectively inhibits Ca2+-dependent PKC isoforms over Ca2+-independent. No inhibitory activity at PKCδ, ε or ζ. Antitumor agent. Active in vitro and in vivo.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 10 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab141413 has been referenced in 6 publications.
- Jeong J et al. Inhibition of ezrin causes PKCa-mediated internalization of erbb2/HER2 tyrosine kinase in breast cancer cells. J Biol Chem 294:887-901 (2019). PubMed: 30463939
- Yang WC et al. Therapeutic hypercapnia reduces blood-brain barrier damage possibly via protein kinase Ce in rats with lateral fluid percussion injury. J Neuroinflammation 16:36 (2019). PubMed: 30760300
- Xue X et al. Protein kinase Ca drives fibroblast activation and kidney fibrosis by stimulating autophagic flux. J Biol Chem 293:11119-11130 (2018). PubMed: 29794026
- Ren J et al. Rictor/mammalian target of rapamycin complex 2 promotes macrophage activation and kidney fibrosis. J Pathol 242:488-499 (2017). PubMed: 28585302
- Pacitto R et al. CXCL12-induced macropinocytosis modulates two distinct pathways to activate mTORC1 in macrophages. J Leukoc Biol 101:683-692 (2017). PubMed: 28250113
- Gu Y et al. Epac-protein kinase C alpha signaling in purinergic P2X3R-mediated hyperalgesia after inflammation. Pain 157:1541-50 (2016). PubMed: 26963850