Overview

  • Product name

    Go 6976, PKC inhibitor
  • Description

    Potent PKC inhibitor. Selective for PKCα and PKCβ
  • Biological description

    Potent, selective PKC inhibitor (IC50 values are 2.3 and 6.2 nM at PKCα and β1, respectively). Selectively inhibits Ca2+-dependent PKC isoforms over Ca2+-independent. No inhibitory activity at PKCδ, ε or ζ. Antitumor agent. Active in vitro and in vivo.

  • Purity

    > 99%
  • CAS Number

    136194-77-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile
  • Molecular weight

    378.43
  • Molecular formula

    C24H18N4O
  • PubChem identifier

    3501
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN1C2=CC=CC=C2C3=C4C(=C5C6=CC=CC=C6N(C5=C31)CCC#N)CNC4=O
  • Source

    Synthetic

  • Research areas

Associated products

References

This product has been referenced in:

  • Feng Z  et al. Chk1 inhibitor Gö6976 enhances the sensitivity of nasopharyngeal carcinoma cells to radiotherapy and chemotherapy in vitro and in vivo. Cancer Lett 297:190-7 (2010). Read more (PubMed: 20619533) »
  • Nikodemova M  et al. Minocycline down-regulates MHC II expression in microglia and macrophages through inhibition of IRF-1 and protein kinase C (PKC)alpha/betaII. J Biol Chem 282:15208-16 (2007). Read more (PubMed: 17395590) »
  • Martiny-Baron G  et al. Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976. J Biol Chem 268:9194-7 (1993). Read more (PubMed: 8486620) »
See all 4 Publications for this product

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