Overview

  • Product name

    Gossypin, Chk1/Cdc25C activator
  • Description

    Chk1/Cdc25C activator. Antioxidant agent.
  • Biological description

    Chk1/Cdc25C activator. Antioxidant agent. Induces G2/M cell cycle arrest. Reduces lipid peroxidation. Shows antitumor, anti-ischemic and neuroprotective effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    652-78-8
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Bhaskaran S  et al. Gossypin as a novel selective dual inhibitor of V-RAF murine sarcoma viral oncogene homolog B1 and cyclin-dependent kinase 4 for melanoma. Mol Cancer Ther 12:361-72 (2013). Read more (PubMed: 23543365) »
  • Shi L  et al. Gossypin induces G2/M arrest in human malignant glioma U251 cells by the activation of Chk1/Cdc25C pathway. Cell Mol Neurobiol 32:289-96 (2012). Read more (PubMed: 21984341) »
  • Chandrashekhar VM  et al. Neuroprotective activity of gossypin from Hibiscus vitifolius against global cerebral ischemia model in rats. Indian J Pharmacol 45:575-80 (0). Read more (PubMed: 24347764) »

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