Gouml 6983, PKC inhibitor (ab144414)
Key features and details
- Potent, fast-acting, broad spectrum PKC inhibitor
- CAS Number: 133053-19-7
- Purity: > 98%
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Gouml 6983, PKC inhibitor -
Description
Potent, fast-acting, broad spectrum PKC inhibitor -
Biological description
Potent, broad spectrum PKC inhibitor (IC50 values are 7, 7, 6, 10, 60 and 20000 nM for PKCα, PKCβ, PKCγ, PKCδ, PKCζ and PKCμ respectively). Shows cardioprotective and anti-ischemic effects in vivo. -
Purity
> 98% -
CAS Number
133053-19-7 -
Chemical structure
Properties
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Chemical name
3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione -
Molecular weight
442.50 -
Molecular formula
C26H26N4O3 -
PubChem identifier
3499 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN(C)CCCN1C=C(C2=C1C=CC(=C2)OC)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54 -
Source
Synthetic
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Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (7)
ab144414 has been referenced in 7 publications.
- D'Souza RS et al. Calcium-stimulated disassembly of focal adhesions mediated by an ORP3/IQSec1 complex. Elife 9:N/A (2020). PubMed: 32234213
- Nguyen GT et al. SKAP2 is required for defense against K. pneumoniae infection and neutrophil respiratory burst. Elife 9:N/A (2020). PubMed: 32352382
- Lv G et al. Inhibition of carrageenan-induced dental inflammatory responses owing to decreased TRPV1 activity by Dexmedetomidine. J Inflamm (Lond) 17:18 (2020). PubMed: 32377171
- De Virgiliis F et al. Enriched conditioning expands the regenerative ability of sensory neurons after spinal cord injury via neuronal intrinsic redox signaling. Nat Commun 11:6425 (2020). PubMed: 33349630
- Kataura T et al. A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers. Autophagy N/A:1-17 (2020). PubMed: 32762399
- König B et al. A FRET sensor of C-terminal movement reveals VRAC activation by plasma membrane DAG signaling rather than ionic strength. Elife 8:N/A (2019). PubMed: 31210638
- Barakat TS et al. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Cell Stem Cell 23:276-288.e8 (2018). PubMed: 30033119