Gouml 6983, PKC inhibitor (ab144414)

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Overview

  • Product name

    Gouml 6983, PKC inhibitor

  • Description

    Potent, fast-acting, broad spectrum PKC inhibitor

  • Biological description

    Potent, broad spectrum PKC inhibitor (IC50 values are 7, 7, 6, 10, 60 and 20000 nM for PKCα, PKCβ, PKCγ, PKCδ, PKCζ and PKCμ respectively). Shows cardioprotective and anti-ischemic effects in vivo.

  • Purity

    > 98%

  • CAS Number

    133053-19-7

  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

  • Molecular weight

    442.50

  • Molecular formula

    C26H26N4O3

  • PubChem identifier

    3499

  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

  • Solubility overview

    Soluble in DMSO to 50 mM

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN(C)CCCN1C=C(C2=C1C=CC(=C2)OC)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54

  • Source

    Synthetic

  • Research areas

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

References

Publishing research using ab144414? Please let us know so that we can cite the reference in this datasheet.

ab144414 has been referenced in 2 publications.

  • König B  et al. A FRET sensor of C-terminal movement reveals VRAC activation by plasma membrane DAG signaling rather than ionic strength. Elife 8:N/A (2019). PubMed: 31210638
  • Barakat TS  et al. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Cell Stem Cell 23:276-288.e8 (2018). PubMed: 30033119

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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