Key features and details
- Potent, fast-acting, broad spectrum PKC inhibitor
- CAS Number: 133053-19-7
- Purity: > 98%
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Product nameGouml 6983, PKC inhibitor
DescriptionPotent, fast-acting, broad spectrum PKC inhibitor
Biological descriptionPotent, broad spectrum PKC inhibitor (IC50 values are 7, 7, 6, 10, 60 and 20000 nM for PKCα, PKCβ, PKCγ, PKCδ, PKCζ and PKCμ respectively). Shows cardioprotective and anti-ischemic effects in vivo.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 50 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab144414 has been referenced in 5 publications.
- D'Souza RS et al. Calcium-stimulated disassembly of focal adhesions mediated by an ORP3/IQSec1 complex. Elife 9:N/A (2020). PubMed: 32234213
- Nguyen GT et al. SKAP2 is required for defense against K. pneumoniae infection and neutrophil respiratory burst. Elife 9:N/A (2020). PubMed: 32352382
- Lv G et al. Inhibition of carrageenan-induced dental inflammatory responses owing to decreased TRPV1 activity by Dexmedetomidine. J Inflamm (Lond) 17:18 (2020). PubMed: 32377171
- König B et al. A FRET sensor of C-terminal movement reveals VRAC activation by plasma membrane DAG signaling rather than ionic strength. Elife 8:N/A (2019). PubMed: 31210638
- Barakat TS et al. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Cell Stem Cell 23:276-288.e8 (2018). PubMed: 30033119