Overview

  • Product name

  • Description

    Rabbit polyclonal to gp78
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide corresponding to Human gp78 aa 370-400 (internal sequence) conjugated to keyhole limpet haemocyanin. NP_001135.3.
    Sequence:

    EQDTSCPTCRMSLNIADNNRVREEHQGENLD


    Database link: Q9UKV5

  • Positive control

    • Human placenta tissue; T47D cell lysate.
  • General notes

    Previously labelled as AMFR. 

Properties

Applications

Our Abpromise guarantee covers the use of ab191163 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 73 kDa.
IHC-P 1/50.

Target

  • Function

    E3 ubiquitin-protein ligase which can target both itself and other proteins including CD3D and APOB for proteasomal degradation. Mediates polyubiquitination of CYP3A4. Specific receptor for the autocrine motility factor. Mediates tumor invasion and metastasis. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulun that are retrotranslocated in the cytosol. Promotes ubiquitination of misfolded proteins such as mutant CFTR; proposed to mediate sequential ubiquitination by recognizing already ubiquitin-conjugated substrates and to cooperate with E3 ubiquitin-protein ligase RNF5.
  • Pathway

    Protein modification; protein ubiquitination.
  • Sequence similarities

    Contains 1 CUE domain.
    Contains 1 RING-type zinc finger.
  • Cellular localization

    Endoplasmic reticulum membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • AMF receptor antibody
    • AMF receptor isoform 1 antibody
    • AMF receptor isoform 2 antibody
    • AMFR antibody
    • AMFR2_HUMAN antibody
    • Autocrine motility factor receptor antibody
    • Autocrine motility factor receptor precursor, isoform 1 antibody
    • Autocrine motility factor receptor precursor, isoform 2 antibody
    • E3 ubiquitin-protein ligase AMFR antibody
    • gp78 antibody
    • isoform 2 antibody
    • RING finger protein 45 antibody
    • RNF 45 antibody
    • RNF45 antibody
    see all

Images

  • Anti-gp78 antibody (ab191163) at 1/1000 dilution + T47D cell lysate at 35 µg

    Predicted band size: 73 kDa

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human placenta tissue labeling gp78 with ab191163 at 1/50 dilution.

References

ab191163 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab191163.
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