GpCp (GMPCP), GDP methylene analog (ab146663)

Overview

  • Product name

    GpCp (GMPCP), GDP methylene analog
  • Description

    GDP methylene analog
  • Alternative names

    • GMPCP
  • Biological description

    GDP methylene analog. Contains methylene group replacing the α and β oxygen. Incorporates into hydrolyzable microtubule subunits. Related GTP analog GMPPCP (ab146660) is also available.
  • Purity

    > 95%
  • CAS Number

    32381-15-0
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    441.23
  • Molecular formula

    C11H17N5O10P2
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Vulevic B  et al. Role of guanine nucleotides in the vinblastine-induced self-association of tubulin: effects of guanosine alpha,beta-methylenetriphosphate and guanosine alpha,beta-methylenediphosphate. Biochemistry 36:12828-35 (1997). Read more (PubMed: 9335540) »
  • Hyman AA  et al. Structural changes accompanying GTP hydrolysis in microtubules: information from a slowly hydrolyzable analogue guanylyl-(alpha,beta)-methylene-diphosphonate. J Cell Biol 128:117-25 (1995). Read more (PubMed: 7822409) »
  • Löwe J & Amos LA Helical tubes of FtsZ from Methanococcus jannaschii. Biol Chem 381:993-9 (0). Read more (PubMed: 11076032) »

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